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Population-level prevalence of detectable HIV viremia in people who inject drugs (PWID) in Ukraine: Implications for HIV treatment and case finding interventions

Achievement of viral load suppression among people living with HIV is one of the most important goals for effective HIV epidemic response. In Ukraine, people who inject drugs (PWID) experience the largest HIV burden. At the same time, this group disproportionally missed out in HIV treatment services...

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Autores principales: Sazonova, Yana, Kulchynska, Roksolana, Azarskova, Marianna, Liulchuk, Mariia, Salyuk, Tetiana, Doan, Ivan, Barzilay, Ezra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602286/
https://www.ncbi.nlm.nih.gov/pubmed/37883454
http://dx.doi.org/10.1371/journal.pone.0290661
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author Sazonova, Yana
Kulchynska, Roksolana
Azarskova, Marianna
Liulchuk, Mariia
Salyuk, Tetiana
Doan, Ivan
Barzilay, Ezra
author_facet Sazonova, Yana
Kulchynska, Roksolana
Azarskova, Marianna
Liulchuk, Mariia
Salyuk, Tetiana
Doan, Ivan
Barzilay, Ezra
author_sort Sazonova, Yana
collection PubMed
description Achievement of viral load suppression among people living with HIV is one of the most important goals for effective HIV epidemic response. In Ukraine, people who inject drugs (PWID) experience the largest HIV burden. At the same time, this group disproportionally missed out in HIV treatment services. We performed a secondary data analysis of the national-wide cross-sectional bio-behavioral surveillance survey among PWID to assess the population-level prevalence of detectable HIV viremia and identify key characteristics that explain the outcome. Overall, 11.4% of PWID or 52.6% of HIV-positive PWID had a viral load level that exceeded the 1,000 copies/mL threshold. In the group of HIV-positive PWID, the detectable viremia was attributed to younger age, monthly income greater than minimum wage, lower education level, and non-usage of antiretroviral therapy (ART) and opioid agonistic therapy. Compared with HIV-negative PWID, the HIV-positive group with detectable viremia was more likely to be female, represented the middle age group (35–49 years old), had low education and monthly income levels, used opioid drugs, practiced risky injection behavior, and had previous incarceration history. Implementing the HIV case identification and ART linkage interventions focused on the most vulnerable PWID sub-groups might help closing the gaps in ART service coverage and increasing the proportion of HIV-positive PWID with viral load suppression.
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spelling pubmed-106022862023-10-27 Population-level prevalence of detectable HIV viremia in people who inject drugs (PWID) in Ukraine: Implications for HIV treatment and case finding interventions Sazonova, Yana Kulchynska, Roksolana Azarskova, Marianna Liulchuk, Mariia Salyuk, Tetiana Doan, Ivan Barzilay, Ezra PLoS One Research Article Achievement of viral load suppression among people living with HIV is one of the most important goals for effective HIV epidemic response. In Ukraine, people who inject drugs (PWID) experience the largest HIV burden. At the same time, this group disproportionally missed out in HIV treatment services. We performed a secondary data analysis of the national-wide cross-sectional bio-behavioral surveillance survey among PWID to assess the population-level prevalence of detectable HIV viremia and identify key characteristics that explain the outcome. Overall, 11.4% of PWID or 52.6% of HIV-positive PWID had a viral load level that exceeded the 1,000 copies/mL threshold. In the group of HIV-positive PWID, the detectable viremia was attributed to younger age, monthly income greater than minimum wage, lower education level, and non-usage of antiretroviral therapy (ART) and opioid agonistic therapy. Compared with HIV-negative PWID, the HIV-positive group with detectable viremia was more likely to be female, represented the middle age group (35–49 years old), had low education and monthly income levels, used opioid drugs, practiced risky injection behavior, and had previous incarceration history. Implementing the HIV case identification and ART linkage interventions focused on the most vulnerable PWID sub-groups might help closing the gaps in ART service coverage and increasing the proportion of HIV-positive PWID with viral load suppression. Public Library of Science 2023-10-26 /pmc/articles/PMC10602286/ /pubmed/37883454 http://dx.doi.org/10.1371/journal.pone.0290661 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Sazonova, Yana
Kulchynska, Roksolana
Azarskova, Marianna
Liulchuk, Mariia
Salyuk, Tetiana
Doan, Ivan
Barzilay, Ezra
Population-level prevalence of detectable HIV viremia in people who inject drugs (PWID) in Ukraine: Implications for HIV treatment and case finding interventions
title Population-level prevalence of detectable HIV viremia in people who inject drugs (PWID) in Ukraine: Implications for HIV treatment and case finding interventions
title_full Population-level prevalence of detectable HIV viremia in people who inject drugs (PWID) in Ukraine: Implications for HIV treatment and case finding interventions
title_fullStr Population-level prevalence of detectable HIV viremia in people who inject drugs (PWID) in Ukraine: Implications for HIV treatment and case finding interventions
title_full_unstemmed Population-level prevalence of detectable HIV viremia in people who inject drugs (PWID) in Ukraine: Implications for HIV treatment and case finding interventions
title_short Population-level prevalence of detectable HIV viremia in people who inject drugs (PWID) in Ukraine: Implications for HIV treatment and case finding interventions
title_sort population-level prevalence of detectable hiv viremia in people who inject drugs (pwid) in ukraine: implications for hiv treatment and case finding interventions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602286/
https://www.ncbi.nlm.nih.gov/pubmed/37883454
http://dx.doi.org/10.1371/journal.pone.0290661
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