Anti‐PD‐1/Her2 Bispecific Antibody IBI315 Enhances the Treatment Effect of Her2‐Positive Gastric Cancer through Gasdermin B‐Cleavage Induced Pyroptosis

The majority of patients with human epidermal growth factor receptor 2 (Her2)‐positive gastric cancer develop refractory to Her2‐targeted therapy, where upregulation of immune checkpoints plays an essential role. Herein, a recombinant fully human IgG1 bispecific antibody IBI315 targeting both PD‐1 a...

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Detalles Bibliográficos
Autores principales: Lin, Wu, Zhang, Yingzi, Yang, Yan, Lin, Ben, Zhu, Mengjia, Xu, Jinling, Chen, YiRan, Wu, Weiwei, Chen, Bingliang, Chen, Xiangliu, Liu, Jin, Wang, Haohao, Teng, Fei, Yu, Xiongfei, Wang, Haiyong, Lu, Jun, Zhou, Quan, Teng, Lisong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602533/
https://www.ncbi.nlm.nih.gov/pubmed/37587833
http://dx.doi.org/10.1002/advs.202303908

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