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Multifunctional Au@AgBiS(2) Nanoparticles as High‐Efficiency Radiosensitizers to Induce Pyroptosis for Cancer Radioimmunotherapy
Radiotherapy (RT), a widely used clinical treatment modality for cancer, uses high‐energy irradiation for reactive oxygen species (ROS) production and DNA damage. However, its therapeutic effect is primarily limited owing to insufficient DNA damage to tumors and harmful effects on normal tissues. He...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602534/ https://www.ncbi.nlm.nih.gov/pubmed/37688340 http://dx.doi.org/10.1002/advs.202302141 |
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author | Xiao, Liang Chen, Benjin Wang, Wanni Tian, Tian Qian, Haisheng Li, Xiaohu Yu, Yongqiang |
author_facet | Xiao, Liang Chen, Benjin Wang, Wanni Tian, Tian Qian, Haisheng Li, Xiaohu Yu, Yongqiang |
author_sort | Xiao, Liang |
collection | PubMed |
description | Radiotherapy (RT), a widely used clinical treatment modality for cancer, uses high‐energy irradiation for reactive oxygen species (ROS) production and DNA damage. However, its therapeutic effect is primarily limited owing to insufficient DNA damage to tumors and harmful effects on normal tissues. Herein, a core‐shell structure of metal–semiconductors (Au@AgBiS(2) nanoparticles) that can function as pyroptosis inducers to both kill cancer cells directly and trigger a robust anti‐tumor immune against 4T1 triple‐negative murine breast cancer and metastasis is rationally designed. Metal‐semiconductor composites can enhance the generation of considerable ROS and simultaneously DNA damage for RT sensitization. Moreover, Au@AgBiS(2), a pyroptosis inducer, induces caspase‐3 protein activation, gasdermin E cleavage, and the release of damage‐associated molecular patterns. In vivo studies in BALB/c mice reveal that Au@AgBiS(2) nanoparticles combined with RT exhibit remarkable antitumor immune activity, preventing tumor growth, and lung metastasis. Therefore, this core‐shell structure is an alternative for designing highly effective radiosensitizers for radioimmunotherapy. |
format | Online Article Text |
id | pubmed-10602534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106025342023-10-27 Multifunctional Au@AgBiS(2) Nanoparticles as High‐Efficiency Radiosensitizers to Induce Pyroptosis for Cancer Radioimmunotherapy Xiao, Liang Chen, Benjin Wang, Wanni Tian, Tian Qian, Haisheng Li, Xiaohu Yu, Yongqiang Adv Sci (Weinh) Research Articles Radiotherapy (RT), a widely used clinical treatment modality for cancer, uses high‐energy irradiation for reactive oxygen species (ROS) production and DNA damage. However, its therapeutic effect is primarily limited owing to insufficient DNA damage to tumors and harmful effects on normal tissues. Herein, a core‐shell structure of metal–semiconductors (Au@AgBiS(2) nanoparticles) that can function as pyroptosis inducers to both kill cancer cells directly and trigger a robust anti‐tumor immune against 4T1 triple‐negative murine breast cancer and metastasis is rationally designed. Metal‐semiconductor composites can enhance the generation of considerable ROS and simultaneously DNA damage for RT sensitization. Moreover, Au@AgBiS(2), a pyroptosis inducer, induces caspase‐3 protein activation, gasdermin E cleavage, and the release of damage‐associated molecular patterns. In vivo studies in BALB/c mice reveal that Au@AgBiS(2) nanoparticles combined with RT exhibit remarkable antitumor immune activity, preventing tumor growth, and lung metastasis. Therefore, this core‐shell structure is an alternative for designing highly effective radiosensitizers for radioimmunotherapy. John Wiley and Sons Inc. 2023-09-08 /pmc/articles/PMC10602534/ /pubmed/37688340 http://dx.doi.org/10.1002/advs.202302141 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Xiao, Liang Chen, Benjin Wang, Wanni Tian, Tian Qian, Haisheng Li, Xiaohu Yu, Yongqiang Multifunctional Au@AgBiS(2) Nanoparticles as High‐Efficiency Radiosensitizers to Induce Pyroptosis for Cancer Radioimmunotherapy |
title | Multifunctional Au@AgBiS(2) Nanoparticles as High‐Efficiency Radiosensitizers to Induce Pyroptosis for Cancer Radioimmunotherapy |
title_full | Multifunctional Au@AgBiS(2) Nanoparticles as High‐Efficiency Radiosensitizers to Induce Pyroptosis for Cancer Radioimmunotherapy |
title_fullStr | Multifunctional Au@AgBiS(2) Nanoparticles as High‐Efficiency Radiosensitizers to Induce Pyroptosis for Cancer Radioimmunotherapy |
title_full_unstemmed | Multifunctional Au@AgBiS(2) Nanoparticles as High‐Efficiency Radiosensitizers to Induce Pyroptosis for Cancer Radioimmunotherapy |
title_short | Multifunctional Au@AgBiS(2) Nanoparticles as High‐Efficiency Radiosensitizers to Induce Pyroptosis for Cancer Radioimmunotherapy |
title_sort | multifunctional au@agbis(2) nanoparticles as high‐efficiency radiosensitizers to induce pyroptosis for cancer radioimmunotherapy |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602534/ https://www.ncbi.nlm.nih.gov/pubmed/37688340 http://dx.doi.org/10.1002/advs.202302141 |
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