Cargando…

Nt-acetylation-independent turnover of SQUALENE EPOXIDASE 1 by Arabidopsis DOA10-like E3 ligases

The acetylation-dependent (Ac/)N-degron pathway degrades proteins through recognition of their acetylated N-termini (Nt) by E3 ligases called Ac/N-recognins. To date, specific Ac/N-recognins have not been defined in plants. Here we used molecular, genetic, and multiomics approaches to characterize p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Etherington, Ross D, Bailey, Mark, Boyer, Jean-Baptiste, Armbruster, Laura, Cao, Xulyu, Coates, Juliet C, Meinnel, Thierry, Wirtz, Markus, Giglione, Carmela, Gibbs, Daniel J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602611/ https://www.ncbi.nlm.nih.gov/pubmed/37427787 http://dx.doi.org/10.1093/plphys/kiad406

Ejemplares similares

Functional characterization of squalene synthase and squalene epoxidase in Taraxacum koksaghyz
por: Unland, Kristina, et al.
Publicado: (2018)

Accumulation of Squalene in a Microalga Chlamydomonas reinhardtii by Genetic Modification of Squalene Synthase and Squalene Epoxidase Genes
por: Kajikawa, Masataka, et al.
Publicado: (2015)

Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
por: Padyana, Anil K., et al.
Publicado: (2019)

The shape of human squalene epoxidase expands the arsenal against cancer
por: Brown, Andrew J., et al.
Publicado: (2019)

Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4
por: Foresti, Ombretta, et al.
Publicado: (2013)

Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC
por: Zhao, Xinyuan, et al.
Publicado: (2023)

Lipid saturation induces degradation of squalene epoxidase for sterol homeostasis and cell survival
por: Huang, Leng-Jie, et al.
Publicado: (2022)

p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer
por: Fischer, Martin
Publicado: (2023)

Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock
por: Hull, Claire M, et al.
Publicado: (2014)

Squalene synthase predicts poor prognosis in stage I‐III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression
por: Jiang, Huihong, et al.
Publicado: (2022)

Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer
por: Brown, David N., et al.
Publicado: (2016)

Isolation and Characterization of Two Squalene Epoxidase Genes from Botryococcus braunii, Race B
por: Uchida, Hidenobu, et al.
Publicado: (2015)

Antifungal Susceptibility and Mutations in the Squalene Epoxidase Gene in Dermatophytes of the Trichophyton mentagrophytes Species Complex
por: Kong, Xue, et al.
Publicado: (2021)

Emergence of Terbinafine Resistant Trichophyton mentagrophytes in Iran, Harboring Mutations in the Squalene Epoxidase (SQLE) Gene
por: Taghipour, Simin, et al.
Publicado: (2020)

Squalene epoxidase expression is associated with breast tumor progression and with a poor prognosis in breast cancer
por: Kim, Nah Ihm, et al.
Publicado: (2021)

Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis
por: Li, Chuangen, et al.
Publicado: (2022)

Novel Insight into the Role of Squalene Epoxidase (SQLE) Gene in Determining Milk Production Traits in Buffalo
por: Chen, Chao, et al.
Publicado: (2023)

Methyl jasmonate promote protostane triterpenes accumulation by up-regulating the expression of squalene epoxidases in Alisma orientale
por: Tian, Rong, et al.
Publicado: (2019)

Inhibition of squalene epoxidase linking with PI3K/AKT signaling pathway suppresses endometrial cancer
por: Ma, Liangjian, et al.
Publicado: (2023)

Squalene epoxidase plays a critical role in determining pig meat quality by regulating adipogenesis, myogenesis, and ROS scavengers
por: Ha, Jeongim, et al.
Publicado: (2017)

Intrinsic resistance to terbinafine among human and animal isolates of Trichophyton mentagrophytes related to amino acid substitution in the squalene epoxidase
por: Łagowski, Dominik, et al.
Publicado: (2020)

High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC
por: Shen, Tingting, et al.
Publicado: (2020)

A Continuous Assay Set to Screen and Characterize Novel Protein N-Acetyltransferases Unveils Rice General Control Non-repressible 5-Related N-Acetyltransferase2 Activity
por: Asensio, Thomas, et al.
Publicado: (2022)

Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal‐regulated kinase signaling
por: Ge, Hong, et al.
Publicado: (2019)

Genome‐Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1
por: Koizumi, Yukio, et al.
Publicado: (2019)

Squalene epoxidase‐induced cholesteryl ester accumulation promotes nasopharyngeal carcinoma development by activating PI3K/AKT signaling
por: Li, Liming, et al.
Publicado: (2020)

Squalene Epoxidase Correlates E-Cadherin Expression and Overall Survival in Colorectal Cancer Patients: The Impact on Prognosis and Correlation to Clinicopathologic Features
por: Kim, Joo Heon, et al.
Publicado: (2019)

Squalene epoxidase/SQLE is a candidate target for treatment of colorectal cancers with p53 mutation and elevated c-MYC expression
por: Du, Yuyun, et al.
Publicado: (2023)

Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis
por: Linster, Eric, et al.
Publicado: (2015)

Point mutations in the squalene epoxidase gene of Indian ITS genotype VIII T. mentagrophytes identified after DNA isolation from infected scales
por: Burmester, Anke, et al.
Publicado: (2019)

A small H(2)O-soluble ingredient of royal jelly lower cholesterol levels in liver cells by suppressing squalene epoxidase
por: Wang, Chi, et al.
Publicado: (2022)

Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1‐mediated MAPK signaling
por: He, Luwei, et al.
Publicado: (2021)

Dual lysine and N‐terminal acetyltransferases reveal the complexity underpinning protein acetylation
por: Bienvenut, Willy V, et al.
Publicado: (2020)

The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron
por: Habeck, Gregor, et al.
Publicado: (2015)

The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron
por: Habeck, Gregor, et al.
Publicado: (2015)

Spatial control of lipid droplet proteins by the ERAD ubiquitin ligase Doa10
por: Ruggiano, Annamaria, et al.
Publicado: (2016)

EnCOUNTer: a parsing tool to uncover the mature N-terminus of organelle-targeted proteins in complex samples
por: Bienvenut, Willy Vincent, et al.
Publicado: (2017)

Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease
por: Helms, M W, et al.
Publicado: (2008)

HYPK promotes the activity of the N(α)-acetyltransferase A complex to determine proteostasis of nonAc-X(2)/N-degron–containing proteins
por: Miklánková, Pavlína, et al.
Publicado: (2022)

Transcriptome-wide identification of squalene epoxidase genes from Glycyrrhiza glabra L.: expression analysis and heterologous expression of GgSQE1 suggest important role in terpenoid biosynthesis
por: Manzoor, Malik Muzafar, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_b9qchab0k8ab3dq357jp3mipk0