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Endoscopic screening of the upper gastrointestinal tract for second primary tumors in patients with head and neck cancer in a Western country

Background  Patients with head and neck squamous cell carcinoma (HNSCC) can develop second primary tumors (SPTs) in the esophagus. Endoscopic screening could lead to detection of SPTs at early stages and improve survival. Methods  We performed a prospective endoscopic screening study in patients wit...

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Autores principales: van Tilburg, Laurelle, van de Ven, Steffi E. M., de Jonge, Pieter Jan F., de Graaf, Wilmar, Spaander, Manon C. W., Nikkessen, Suzan, Hardillo, Jose A., Sewnaik, Aniel, Monserez, Dominiek A., Mast, Hetty, Keereweer, Stijn, Bruno, Marco J., Baatenburg de Jong, Robert J., Koch, Arjun D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602659/
https://www.ncbi.nlm.nih.gov/pubmed/37328150
http://dx.doi.org/10.1055/a-2111-5935
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author van Tilburg, Laurelle
van de Ven, Steffi E. M.
de Jonge, Pieter Jan F.
de Graaf, Wilmar
Spaander, Manon C. W.
Nikkessen, Suzan
Hardillo, Jose A.
Sewnaik, Aniel
Monserez, Dominiek A.
Mast, Hetty
Keereweer, Stijn
Bruno, Marco J.
Baatenburg de Jong, Robert J.
Koch, Arjun D.
author_facet van Tilburg, Laurelle
van de Ven, Steffi E. M.
de Jonge, Pieter Jan F.
de Graaf, Wilmar
Spaander, Manon C. W.
Nikkessen, Suzan
Hardillo, Jose A.
Sewnaik, Aniel
Monserez, Dominiek A.
Mast, Hetty
Keereweer, Stijn
Bruno, Marco J.
Baatenburg de Jong, Robert J.
Koch, Arjun D.
author_sort van Tilburg, Laurelle
collection PubMed
description Background  Patients with head and neck squamous cell carcinoma (HNSCC) can develop second primary tumors (SPTs) in the esophagus. Endoscopic screening could lead to detection of SPTs at early stages and improve survival. Methods  We performed a prospective endoscopic screening study in patients with curably treated HNSCC diagnosed between January 2017–July 2021 in a Western country. Screening was performed synchronously (< 6 months) or metachronously (≥ 6 months) after HNSCC diagnosis. Routine imaging for HNSCC consisted of flexible transnasal endoscopy with positron emission tomography/computed tomography or magnetic resonance imaging, depending on primary HNSCC location. The primary outcome was prevalence of SPTs, defined as presence of esophageal high grade dysplasia or squamous cell carcinoma. Results  202 patients (mean age 65 years, 80.7 % male) underwent 250 screening endoscopies. HNSCC was located in the oropharynx (31.9 %), hypopharynx (26.9 %), larynx (22.2 %), and oral cavity (18.5 %). Endoscopic screening was performed within 6 months (34.0 %), 6 months to 1 year (8.0 %), 1–2 years (33.6 %), and 2–5 years (24.4 %) after HNSCC diagnosis. We detected 11 SPTs in 10 patients (5.0 %, 95 %CI 2.4 %–8.9 %) during synchronous (6/85) and metachronous (5/165) screening. Most patients had early stage SPTs (90 %) and were treated with curative intent with endoscopic resection (80 %). No SPTs in screened patients were detected with routine imaging for HNSCC before endoscopic screening. Conclusion  In 5 % of patients with HNSCC, an SPT was detected with endoscopic screening. Endoscopic screening should be considered in selected HNSCC patients to detect early stage SPTs, based on highest SPT risk and life expectancy according to HNSCC and comorbidities.
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spelling pubmed-106026592023-10-27 Endoscopic screening of the upper gastrointestinal tract for second primary tumors in patients with head and neck cancer in a Western country van Tilburg, Laurelle van de Ven, Steffi E. M. de Jonge, Pieter Jan F. de Graaf, Wilmar Spaander, Manon C. W. Nikkessen, Suzan Hardillo, Jose A. Sewnaik, Aniel Monserez, Dominiek A. Mast, Hetty Keereweer, Stijn Bruno, Marco J. Baatenburg de Jong, Robert J. Koch, Arjun D. Endoscopy Background  Patients with head and neck squamous cell carcinoma (HNSCC) can develop second primary tumors (SPTs) in the esophagus. Endoscopic screening could lead to detection of SPTs at early stages and improve survival. Methods  We performed a prospective endoscopic screening study in patients with curably treated HNSCC diagnosed between January 2017–July 2021 in a Western country. Screening was performed synchronously (< 6 months) or metachronously (≥ 6 months) after HNSCC diagnosis. Routine imaging for HNSCC consisted of flexible transnasal endoscopy with positron emission tomography/computed tomography or magnetic resonance imaging, depending on primary HNSCC location. The primary outcome was prevalence of SPTs, defined as presence of esophageal high grade dysplasia or squamous cell carcinoma. Results  202 patients (mean age 65 years, 80.7 % male) underwent 250 screening endoscopies. HNSCC was located in the oropharynx (31.9 %), hypopharynx (26.9 %), larynx (22.2 %), and oral cavity (18.5 %). Endoscopic screening was performed within 6 months (34.0 %), 6 months to 1 year (8.0 %), 1–2 years (33.6 %), and 2–5 years (24.4 %) after HNSCC diagnosis. We detected 11 SPTs in 10 patients (5.0 %, 95 %CI 2.4 %–8.9 %) during synchronous (6/85) and metachronous (5/165) screening. Most patients had early stage SPTs (90 %) and were treated with curative intent with endoscopic resection (80 %). No SPTs in screened patients were detected with routine imaging for HNSCC before endoscopic screening. Conclusion  In 5 % of patients with HNSCC, an SPT was detected with endoscopic screening. Endoscopic screening should be considered in selected HNSCC patients to detect early stage SPTs, based on highest SPT risk and life expectancy according to HNSCC and comorbidities. Georg Thieme Verlag KG 2023-07-25 /pmc/articles/PMC10602659/ /pubmed/37328150 http://dx.doi.org/10.1055/a-2111-5935 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle van Tilburg, Laurelle
van de Ven, Steffi E. M.
de Jonge, Pieter Jan F.
de Graaf, Wilmar
Spaander, Manon C. W.
Nikkessen, Suzan
Hardillo, Jose A.
Sewnaik, Aniel
Monserez, Dominiek A.
Mast, Hetty
Keereweer, Stijn
Bruno, Marco J.
Baatenburg de Jong, Robert J.
Koch, Arjun D.
Endoscopic screening of the upper gastrointestinal tract for second primary tumors in patients with head and neck cancer in a Western country
title Endoscopic screening of the upper gastrointestinal tract for second primary tumors in patients with head and neck cancer in a Western country
title_full Endoscopic screening of the upper gastrointestinal tract for second primary tumors in patients with head and neck cancer in a Western country
title_fullStr Endoscopic screening of the upper gastrointestinal tract for second primary tumors in patients with head and neck cancer in a Western country
title_full_unstemmed Endoscopic screening of the upper gastrointestinal tract for second primary tumors in patients with head and neck cancer in a Western country
title_short Endoscopic screening of the upper gastrointestinal tract for second primary tumors in patients with head and neck cancer in a Western country
title_sort endoscopic screening of the upper gastrointestinal tract for second primary tumors in patients with head and neck cancer in a western country
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602659/
https://www.ncbi.nlm.nih.gov/pubmed/37328150
http://dx.doi.org/10.1055/a-2111-5935
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