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The relationship between cancer and biomechanics
The onset, development, diagnosis, and treatment of cancer involve intricate interactions among various factors, spanning the realms of mechanics, physics, chemistry, and biology. Within our bodies, cells are subject to a variety of forces such as gravity, magnetism, tension, compression, shear stre...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602664/ https://www.ncbi.nlm.nih.gov/pubmed/37901315 http://dx.doi.org/10.3389/fonc.2023.1273154 |
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author | Bao, Liqi Kong, Hongru Ja, Yang Wang, Chengchao Qin, Lei Sun, Hongwei Dai, Shengjie |
author_facet | Bao, Liqi Kong, Hongru Ja, Yang Wang, Chengchao Qin, Lei Sun, Hongwei Dai, Shengjie |
author_sort | Bao, Liqi |
collection | PubMed |
description | The onset, development, diagnosis, and treatment of cancer involve intricate interactions among various factors, spanning the realms of mechanics, physics, chemistry, and biology. Within our bodies, cells are subject to a variety of forces such as gravity, magnetism, tension, compression, shear stress, and biological static force/hydrostatic pressure. These forces are perceived by mechanoreceptors as mechanical signals, which are then transmitted to cells through a process known as mechanical transduction. During tumor development, invasion and metastasis, there are significant biomechanical influences on various aspects such as tumor angiogenesis, interactions between tumor cells and the extracellular matrix (ECM), interactions between tumor cells and other cells, and interactions between tumor cells and the circulatory system and vasculature. The tumor microenvironment comprises a complex interplay of cells, ECM and vasculature, with the ECM, comprising collagen, fibronectins, integrins, laminins and matrix metalloproteinases, acting as a critical mediator of mechanical properties and a key component within the mechanical signaling pathway. The vasculature exerts appropriate shear forces on tumor cells, enabling their escape from immune surveillance, facilitating their dissemination in the bloodstream, dictating the trajectory of circulating tumor cells (CTCs) and playing a pivotal role in regulating adhesion to the vessel wall. Tumor biomechanics plays a critical role in tumor progression and metastasis, as alterations in biomechanical properties throughout the malignant transformation process trigger a cascade of changes in cellular behavior and the tumor microenvironment, ultimately culminating in the malignant biological behavior of the tumor. |
format | Online Article Text |
id | pubmed-10602664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106026642023-10-27 The relationship between cancer and biomechanics Bao, Liqi Kong, Hongru Ja, Yang Wang, Chengchao Qin, Lei Sun, Hongwei Dai, Shengjie Front Oncol Oncology The onset, development, diagnosis, and treatment of cancer involve intricate interactions among various factors, spanning the realms of mechanics, physics, chemistry, and biology. Within our bodies, cells are subject to a variety of forces such as gravity, magnetism, tension, compression, shear stress, and biological static force/hydrostatic pressure. These forces are perceived by mechanoreceptors as mechanical signals, which are then transmitted to cells through a process known as mechanical transduction. During tumor development, invasion and metastasis, there are significant biomechanical influences on various aspects such as tumor angiogenesis, interactions between tumor cells and the extracellular matrix (ECM), interactions between tumor cells and other cells, and interactions between tumor cells and the circulatory system and vasculature. The tumor microenvironment comprises a complex interplay of cells, ECM and vasculature, with the ECM, comprising collagen, fibronectins, integrins, laminins and matrix metalloproteinases, acting as a critical mediator of mechanical properties and a key component within the mechanical signaling pathway. The vasculature exerts appropriate shear forces on tumor cells, enabling their escape from immune surveillance, facilitating their dissemination in the bloodstream, dictating the trajectory of circulating tumor cells (CTCs) and playing a pivotal role in regulating adhesion to the vessel wall. Tumor biomechanics plays a critical role in tumor progression and metastasis, as alterations in biomechanical properties throughout the malignant transformation process trigger a cascade of changes in cellular behavior and the tumor microenvironment, ultimately culminating in the malignant biological behavior of the tumor. Frontiers Media S.A. 2023-10-12 /pmc/articles/PMC10602664/ /pubmed/37901315 http://dx.doi.org/10.3389/fonc.2023.1273154 Text en Copyright © 2023 Bao, Kong, Ja, Wang, Qin, Sun and Dai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Bao, Liqi Kong, Hongru Ja, Yang Wang, Chengchao Qin, Lei Sun, Hongwei Dai, Shengjie The relationship between cancer and biomechanics |
title | The relationship between cancer and biomechanics |
title_full | The relationship between cancer and biomechanics |
title_fullStr | The relationship between cancer and biomechanics |
title_full_unstemmed | The relationship between cancer and biomechanics |
title_short | The relationship between cancer and biomechanics |
title_sort | relationship between cancer and biomechanics |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602664/ https://www.ncbi.nlm.nih.gov/pubmed/37901315 http://dx.doi.org/10.3389/fonc.2023.1273154 |
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