Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs

Neurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determine...

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Detalles Bibliográficos
Autores principales: Yun, Taesik, Chae, Yeon, Koo, Yoonhoi, Lee, Dohee, Kim, Hakhyun, Yang, Mhan-Pyo, Kang, Byeong-Teck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602691/
https://www.ncbi.nlm.nih.gov/pubmed/37901103
http://dx.doi.org/10.3389/fvets.2023.1284306
Descripción
Sumario:Neurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determined using a single-molecule array. Serum NfL concentrations were significantly higher in hypoxemic dogs without neurological signs (n = 6, 175.5 pg/mL) than in healthy dogs (n = 15, 15.9 pg/mL; p < 0.0001). Therefore, neuronal injury should be considered in dogs with hypoxemia caused by cardiopulmonary diseases, even in the absence of neurological signs.

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