Cargando…
Invasion of the bucco-mandibular space by oral squamous cell carcinoma: histopathological analysis of invasion pattern
BACKGROUND: This study aimed to determine the patterns of invasion of oral squamous cell carcinoma (OSCC) into the bucco-mandibular space (BMS) using detailed histopathological analysis and to assess clinical outcomes. METHODS: Patients with OSCC who underwent segmental mandibulectomy or hemi-mandib...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602748/ https://www.ncbi.nlm.nih.gov/pubmed/37901328 http://dx.doi.org/10.3389/fonc.2023.1168376 |
_version_ | 1785126449612587008 |
---|---|
author | Kugimoto, Takuma Nishii, Naoto Oikawa, Yu Kuroshima, Takeshi Hirai, Hideaki Tomioka, Hirofumi Michi, Yasuyuki Kayamori, Kou Sakamoto, Junichiro Iwanaga, Joe Tubbs, R. Shane Ikeda, Tohru Miura, Masahiko Harada, Hiroyuki |
author_facet | Kugimoto, Takuma Nishii, Naoto Oikawa, Yu Kuroshima, Takeshi Hirai, Hideaki Tomioka, Hirofumi Michi, Yasuyuki Kayamori, Kou Sakamoto, Junichiro Iwanaga, Joe Tubbs, R. Shane Ikeda, Tohru Miura, Masahiko Harada, Hiroyuki |
author_sort | Kugimoto, Takuma |
collection | PubMed |
description | BACKGROUND: This study aimed to determine the patterns of invasion of oral squamous cell carcinoma (OSCC) into the bucco-mandibular space (BMS) using detailed histopathological analysis and to assess clinical outcomes. METHODS: Patients with OSCC who underwent segmental mandibulectomy or hemi-mandibulectomy combined with resection of the BMS between 2012 and 2021 were included. The invasions of the BMS were classified into three patterns. Pattern A was defined as a horizontal invasion, Pattern B as a vertical invasion, and Pattern C as an expansive invasion. RESULTS: In total, 109 patients were reviewed. Of these 109 patients, the primary tumor affected the lower gingiva in 78 patients, the buccal mucosa in 18 patients, and was a primary intraosseous carcinoma of the mandible in 13 patients. Invasion of the BMS was significantly associated with a higher pathological T stage, positive/close margins, and lower disease-free survival (DFS) rates. The DFS rates were 86.7% and 66.0% in the BMS non-invasion and invasion groups, respectively. The DFS rates for each type of invasion were 82.1% for Pattern A, 67.4% for Pattern B, and 48.0% for Pattern C (P=0.277). CONCLUSION: Patients with BMS invasion have a poorer prognosis than those without invasion of the BMS. Therefore, adjuvant therapy is necessary, especially in Patterns B and C. Evaluation of preoperative BMS invasion patterns is important for predicting the prognosis of OSCC. |
format | Online Article Text |
id | pubmed-10602748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106027482023-10-27 Invasion of the bucco-mandibular space by oral squamous cell carcinoma: histopathological analysis of invasion pattern Kugimoto, Takuma Nishii, Naoto Oikawa, Yu Kuroshima, Takeshi Hirai, Hideaki Tomioka, Hirofumi Michi, Yasuyuki Kayamori, Kou Sakamoto, Junichiro Iwanaga, Joe Tubbs, R. Shane Ikeda, Tohru Miura, Masahiko Harada, Hiroyuki Front Oncol Oncology BACKGROUND: This study aimed to determine the patterns of invasion of oral squamous cell carcinoma (OSCC) into the bucco-mandibular space (BMS) using detailed histopathological analysis and to assess clinical outcomes. METHODS: Patients with OSCC who underwent segmental mandibulectomy or hemi-mandibulectomy combined with resection of the BMS between 2012 and 2021 were included. The invasions of the BMS were classified into three patterns. Pattern A was defined as a horizontal invasion, Pattern B as a vertical invasion, and Pattern C as an expansive invasion. RESULTS: In total, 109 patients were reviewed. Of these 109 patients, the primary tumor affected the lower gingiva in 78 patients, the buccal mucosa in 18 patients, and was a primary intraosseous carcinoma of the mandible in 13 patients. Invasion of the BMS was significantly associated with a higher pathological T stage, positive/close margins, and lower disease-free survival (DFS) rates. The DFS rates were 86.7% and 66.0% in the BMS non-invasion and invasion groups, respectively. The DFS rates for each type of invasion were 82.1% for Pattern A, 67.4% for Pattern B, and 48.0% for Pattern C (P=0.277). CONCLUSION: Patients with BMS invasion have a poorer prognosis than those without invasion of the BMS. Therefore, adjuvant therapy is necessary, especially in Patterns B and C. Evaluation of preoperative BMS invasion patterns is important for predicting the prognosis of OSCC. Frontiers Media S.A. 2023-10-12 /pmc/articles/PMC10602748/ /pubmed/37901328 http://dx.doi.org/10.3389/fonc.2023.1168376 Text en Copyright © 2023 Kugimoto, Nishii, Oikawa, Kuroshima, Hirai, Tomioka, Michi, Kayamori, Sakamoto, Iwanaga, Tubbs, Ikeda, Miura and Harada https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Kugimoto, Takuma Nishii, Naoto Oikawa, Yu Kuroshima, Takeshi Hirai, Hideaki Tomioka, Hirofumi Michi, Yasuyuki Kayamori, Kou Sakamoto, Junichiro Iwanaga, Joe Tubbs, R. Shane Ikeda, Tohru Miura, Masahiko Harada, Hiroyuki Invasion of the bucco-mandibular space by oral squamous cell carcinoma: histopathological analysis of invasion pattern |
title | Invasion of the bucco-mandibular space by oral squamous cell carcinoma: histopathological analysis of invasion pattern |
title_full | Invasion of the bucco-mandibular space by oral squamous cell carcinoma: histopathological analysis of invasion pattern |
title_fullStr | Invasion of the bucco-mandibular space by oral squamous cell carcinoma: histopathological analysis of invasion pattern |
title_full_unstemmed | Invasion of the bucco-mandibular space by oral squamous cell carcinoma: histopathological analysis of invasion pattern |
title_short | Invasion of the bucco-mandibular space by oral squamous cell carcinoma: histopathological analysis of invasion pattern |
title_sort | invasion of the bucco-mandibular space by oral squamous cell carcinoma: histopathological analysis of invasion pattern |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602748/ https://www.ncbi.nlm.nih.gov/pubmed/37901328 http://dx.doi.org/10.3389/fonc.2023.1168376 |
work_keys_str_mv | AT kugimototakuma invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern AT nishiinaoto invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern AT oikawayu invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern AT kuroshimatakeshi invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern AT hiraihideaki invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern AT tomiokahirofumi invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern AT michiyasuyuki invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern AT kayamorikou invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern AT sakamotojunichiro invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern AT iwanagajoe invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern AT tubbsrshane invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern AT ikedatohru invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern AT miuramasahiko invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern AT haradahiroyuki invasionofthebuccomandibularspacebyoralsquamouscellcarcinomahistopathologicalanalysisofinvasionpattern |