Efficacy of On-line Hemodiafiltration for Rhabdomyolysis Presenting with Acute Kidney Injury Due to Unexpected Drug Abuse

Myoglobin is a well-known cause of acute kidney injury (AKI) due to rhabdomyolysis. However, whether or not removing serum myoglobin by on-line hemodiafiltration (OHDF) improves the kidney function remains unclear. We herein report a patient with a history of methamphetamine abuse who developed AKI...

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Autores principales: Sato, Naokazu, Inagaki, Koji, Takanashi, Masahiro, Muto, Reiko, Kato, Noritoshi, Maruyama, Shoichi, Akahori, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602844/
https://www.ncbi.nlm.nih.gov/pubmed/36792194
http://dx.doi.org/10.2169/internalmedicine.1107-22
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author Sato, Naokazu
Inagaki, Koji
Takanashi, Masahiro
Muto, Reiko
Kato, Noritoshi
Maruyama, Shoichi
Akahori, Toshiyuki
author_facet Sato, Naokazu
Inagaki, Koji
Takanashi, Masahiro
Muto, Reiko
Kato, Noritoshi
Maruyama, Shoichi
Akahori, Toshiyuki
author_sort Sato, Naokazu
collection PubMed
description Myoglobin is a well-known cause of acute kidney injury (AKI) due to rhabdomyolysis. However, whether or not removing serum myoglobin by on-line hemodiafiltration (OHDF) improves the kidney function remains unclear. We herein report a patient with a history of methamphetamine abuse who developed AKI due to rhabdomyolysis. A urinalysis and blood collection results obtained before and after OHDF demonstrated that OHDF improved the kidney function by removing a large amount of serum myoglobin rather than via urinary excretion. In conclusion, OHDF may prevent AKI progression effectively when the urine volume is insufficient.
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spelling pubmed-106028442023-10-28 Efficacy of On-line Hemodiafiltration for Rhabdomyolysis Presenting with Acute Kidney Injury Due to Unexpected Drug Abuse Sato, Naokazu Inagaki, Koji Takanashi, Masahiro Muto, Reiko Kato, Noritoshi Maruyama, Shoichi Akahori, Toshiyuki Intern Med Case Report Myoglobin is a well-known cause of acute kidney injury (AKI) due to rhabdomyolysis. However, whether or not removing serum myoglobin by on-line hemodiafiltration (OHDF) improves the kidney function remains unclear. We herein report a patient with a history of methamphetamine abuse who developed AKI due to rhabdomyolysis. A urinalysis and blood collection results obtained before and after OHDF demonstrated that OHDF improved the kidney function by removing a large amount of serum myoglobin rather than via urinary excretion. In conclusion, OHDF may prevent AKI progression effectively when the urine volume is insufficient. The Japanese Society of Internal Medicine 2023-02-15 2023-10-01 /pmc/articles/PMC10602844/ /pubmed/36792194 http://dx.doi.org/10.2169/internalmedicine.1107-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sato, Naokazu
Inagaki, Koji
Takanashi, Masahiro
Muto, Reiko
Kato, Noritoshi
Maruyama, Shoichi
Akahori, Toshiyuki
Efficacy of On-line Hemodiafiltration for Rhabdomyolysis Presenting with Acute Kidney Injury Due to Unexpected Drug Abuse
title Efficacy of On-line Hemodiafiltration for Rhabdomyolysis Presenting with Acute Kidney Injury Due to Unexpected Drug Abuse
title_full Efficacy of On-line Hemodiafiltration for Rhabdomyolysis Presenting with Acute Kidney Injury Due to Unexpected Drug Abuse
title_fullStr Efficacy of On-line Hemodiafiltration for Rhabdomyolysis Presenting with Acute Kidney Injury Due to Unexpected Drug Abuse
title_full_unstemmed Efficacy of On-line Hemodiafiltration for Rhabdomyolysis Presenting with Acute Kidney Injury Due to Unexpected Drug Abuse
title_short Efficacy of On-line Hemodiafiltration for Rhabdomyolysis Presenting with Acute Kidney Injury Due to Unexpected Drug Abuse
title_sort efficacy of on-line hemodiafiltration for rhabdomyolysis presenting with acute kidney injury due to unexpected drug abuse
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602844/
https://www.ncbi.nlm.nih.gov/pubmed/36792194
http://dx.doi.org/10.2169/internalmedicine.1107-22
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