Depletion of slow-cycling PDGFRα(+)ADAM12(+) mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis

The capacity to survive and thrive in conditions of limited resources and high inflammation is a major driver of tumor malignancy. Here we identified slow-cycling ADAM12(+)PDGFRα(+) mesenchymal stromal cells (MSCs) induced at the tumor margins in mouse models of melanoma, pancreatic cancer and prost...

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Detalles Bibliográficos
Autores principales: Di Carlo, Selene E., Raffenne, Jerome, Varet, Hugo, Ode, Anais, Granados, David Cabrerizo, Stein, Merle, Legendre, Rachel, Tuckermann, Jan, Bousquet, Corinne, Peduto, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602852/
https://www.ncbi.nlm.nih.gov/pubmed/37798557
http://dx.doi.org/10.1038/s41590-023-01642-7

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