Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan

CD8(+) T cells provide robust antiviral immunity, but how epitope-specific T cells evolve across the human lifespan is unclear. Here we defined CD8(+) T cell immunity directed at the prominent influenza epitope HLA-A*02:01-M1(58–66) (A2/M1(58)) across four age groups at phenotypic, transcriptomic, c...

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Detalles Bibliográficos
Autores principales: van de Sandt, Carolien E., Nguyen, Thi H. O., Gherardin, Nicholas A., Crawford, Jeremy Chase, Samir, Jerome, Minervina, Anastasia A., Pogorelyy, Mikhail V., Rizzetto, Simone, Szeto, Christopher, Kaur, Jasveen, Ranson, Nicole, Sonda, Sabrina, Harper, Alice, Redmond, Samuel J., McQuilten, Hayley A., Menon, Tejas, Sant, Sneha, Jia, Xiaoxiao, Pedrina, Kate, Karapanagiotidis, Theo, Cain, Natalie, Nicholson, Suellen, Chen, Zhenjun, Lim, Ratana, Clemens, E. Bridie, Eltahla, Auda, La Gruta, Nicole L., Crowe, Jane, Lappas, Martha, Rossjohn, Jamie, Godfrey, Dale I., Thomas, Paul G., Gras, Stephanie, Flanagan, Katie L., Luciani, Fabio, Kedzierska, Katherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602853/
https://www.ncbi.nlm.nih.gov/pubmed/37749325
http://dx.doi.org/10.1038/s41590-023-01633-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602853/
https://www.ncbi.nlm.nih.gov/pubmed/37749325
http://dx.doi.org/10.1038/s41590-023-01633-8

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