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HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers

Incorporation of histone variant H3.3 comprises active territories of chromatin. Exploring the function of H3.3 in prostate cancer (PC), we found that knockout (KO) of H3.3 chaperone HIRA suppresses PC growth in vitro and in xenograft settings, deregulates androgen-induced gene expression and alters...

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Detalles Bibliográficos
Autores principales:	Morozov, Viacheslav M, Riva, Alberto, Sarwar, Sadia, Kim, Wan-Ju, Li, Jianping, Zhou, Lei, Licht, Jonathan D, Daaka, Yehia, Ishov, Alexander M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602887/ https://www.ncbi.nlm.nih.gov/pubmed/37638746 http://dx.doi.org/10.1093/nar/gkad700

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