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P53 independent pathogenic mechanisms contribute to BubR1 microcephaly

The mosaic variegated aneuploidy (MVA)-associated gene Budding Uninhibited by Benzimidazole 1B (BUB1B) encodes BUBR1, a core member of the spindle assembly checkpoint complex that ensures kinetochore-spindle attachment for faithful chromosome segregation. BUB1B mutation in humans and its deletion in...

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Detalles Bibliográficos
Autores principales:	Sterling, Noelle A., Terry, Bethany K., McDonnell, Julia M., Kim, Seonhee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602889/ https://www.ncbi.nlm.nih.gov/pubmed/37900274 http://dx.doi.org/10.3389/fcell.2023.1282182

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