Quantum biological insights into CRISPR-Cas9 sgRNA efficiency from explainable-AI driven feature engineering

CRISPR-Cas9 tools have transformed genetic manipulation capabilities in the laboratory. Empirical rules-of-thumb have been developed for only a narrow range of model organisms, and mechanistic underpinnings for sgRNA efficiency remain poorly understood. This work establishes a novel feature set and...

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Detalles Bibliográficos
Autores principales: Noshay, Jaclyn M, Walker, Tyler, Alexander, William G, Klingeman, Dawn M, Romero, Jonathon, Walker, Angelica M, Prates, Erica, Eckert, Carrie, Irle, Stephan, Kainer, David, Jacobson, Daniel A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602897/
https://www.ncbi.nlm.nih.gov/pubmed/37738140
http://dx.doi.org/10.1093/nar/gkad736

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