Epigenetic reprogramming of a distal developmental enhancer cluster drives SOX2 overexpression in breast and lung adenocarcinoma

Enhancer reprogramming has been proposed as a key source of transcriptional dysregulation during tumorigenesis, but the molecular mechanisms underlying this process remain unclear. Here, we identify an enhancer cluster required for normal development that is aberrantly activated in breast and lung a...

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Detalles Bibliográficos
Autores principales: Abatti, Luis E, Lado-Fernández, Patricia, Huynh, Linh, Collado, Manuel, Hoffman, Michael M, Mitchell, Jennifer A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602899/
https://www.ncbi.nlm.nih.gov/pubmed/37738673
http://dx.doi.org/10.1093/nar/gkad734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602899/
https://www.ncbi.nlm.nih.gov/pubmed/37738673
http://dx.doi.org/10.1093/nar/gkad734

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