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Advances and Applications of Brain Organoids

Understanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans. Over the past years, an em...

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Detalles Bibliográficos
Autores principales: Li, Yang, Zeng, Peng-Ming, Wu, Jian, Luo, Zhen-Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603019/
https://www.ncbi.nlm.nih.gov/pubmed/37222855
http://dx.doi.org/10.1007/s12264-023-01065-2
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author Li, Yang
Zeng, Peng-Ming
Wu, Jian
Luo, Zhen-Ge
author_facet Li, Yang
Zeng, Peng-Ming
Wu, Jian
Luo, Zhen-Ge
author_sort Li, Yang
collection PubMed
description Understanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans. Over the past years, an emerging model, the “brain organoid” integrated from human pluripotent stem cells, has been developed to mimic developmental processes of the human brain and disease-associated phenotypes to some extent, making it possible to better understand the complex structures and functions of the human brain. In this review, we summarize recent advances in brain organoid technologies and their applications in brain development and diseases, including neurodevelopmental, neurodegenerative, psychiatric diseases, and brain tumors. Finally, we also discuss current limitations and the potential of brain organoids.
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spelling pubmed-106030192023-10-28 Advances and Applications of Brain Organoids Li, Yang Zeng, Peng-Ming Wu, Jian Luo, Zhen-Ge Neurosci Bull Review Understanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans. Over the past years, an emerging model, the “brain organoid” integrated from human pluripotent stem cells, has been developed to mimic developmental processes of the human brain and disease-associated phenotypes to some extent, making it possible to better understand the complex structures and functions of the human brain. In this review, we summarize recent advances in brain organoid technologies and their applications in brain development and diseases, including neurodevelopmental, neurodegenerative, psychiatric diseases, and brain tumors. Finally, we also discuss current limitations and the potential of brain organoids. Springer Nature Singapore 2023-05-24 /pmc/articles/PMC10603019/ /pubmed/37222855 http://dx.doi.org/10.1007/s12264-023-01065-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Li, Yang
Zeng, Peng-Ming
Wu, Jian
Luo, Zhen-Ge
Advances and Applications of Brain Organoids
title Advances and Applications of Brain Organoids
title_full Advances and Applications of Brain Organoids
title_fullStr Advances and Applications of Brain Organoids
title_full_unstemmed Advances and Applications of Brain Organoids
title_short Advances and Applications of Brain Organoids
title_sort advances and applications of brain organoids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603019/
https://www.ncbi.nlm.nih.gov/pubmed/37222855
http://dx.doi.org/10.1007/s12264-023-01065-2
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