Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment

Extracellular matrix (ECM) deposition after central nervous system (CNS) injury leads to inhibitory scarring in humans and other mammals, whereas it facilitates axon regeneration in the zebrafish. However, the molecular basis of these different fates is not understood. Here, we identify small leucin...

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Detalles Bibliográficos
Autores principales: Kolb, Julia, Tsata, Vasiliki, John, Nora, Kim, Kyoohyun, Möckel, Conrad, Rosso, Gonzalo, Kurbel, Veronika, Parmar, Asha, Sharma, Gargi, Karandasheva, Kristina, Abuhattum, Shada, Lyraki, Olga, Beck, Timon, Müller, Paul, Schlüßler, Raimund, Frischknecht, Renato, Wehner, Anja, Krombholz, Nicole, Steigenberger, Barbara, Beis, Dimitris, Takeoka, Aya, Blümcke, Ingmar, Möllmert, Stephanie, Singh, Kanwarpal, Guck, Jochen, Kobow, Katja, Wehner, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603094/
https://www.ncbi.nlm.nih.gov/pubmed/37884489
http://dx.doi.org/10.1038/s41467-023-42339-7

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