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Characteristics and evaluation of atherosclerotic plaques: an overview of state-of-the-art techniques

Atherosclerosis is an important cause of cerebrovascular and cardiovascular disease (CVD). Lipid infiltration, inflammation, and altered vascular stress are the critical mechanisms that cause atherosclerotic plaque formation. The hallmarks of the progression of atherosclerosis include plaque ulcerat...

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Autores principales: He, Zhiwei, Luo, Jiaying, Lv, Mengna, Li, Qingwen, Ke, Wei, Niu, Xuan, Zhang, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603250/
https://www.ncbi.nlm.nih.gov/pubmed/37900593
http://dx.doi.org/10.3389/fneur.2023.1159288
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author He, Zhiwei
Luo, Jiaying
Lv, Mengna
Li, Qingwen
Ke, Wei
Niu, Xuan
Zhang, Zhaohui
author_facet He, Zhiwei
Luo, Jiaying
Lv, Mengna
Li, Qingwen
Ke, Wei
Niu, Xuan
Zhang, Zhaohui
author_sort He, Zhiwei
collection PubMed
description Atherosclerosis is an important cause of cerebrovascular and cardiovascular disease (CVD). Lipid infiltration, inflammation, and altered vascular stress are the critical mechanisms that cause atherosclerotic plaque formation. The hallmarks of the progression of atherosclerosis include plaque ulceration, rupture, neovascularization, and intraplaque hemorrhage, all of which are closely associated with the occurrence of CVD. Assessing the severity of atherosclerosis and plaque vulnerability is crucial for the prevention and treatment of CVD. Integrating imaging techniques for evaluating the characteristics of atherosclerotic plaques with computer simulations yields insights into plaque inflammation levels, spatial morphology, and intravascular stress distribution, resulting in a more realistic and accurate estimation of plaque state. Here, we review the characteristics and advancing techniques used to analyze intracranial and extracranial atherosclerotic plaques to provide a comprehensive understanding of atheroma.
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spelling pubmed-106032502023-10-28 Characteristics and evaluation of atherosclerotic plaques: an overview of state-of-the-art techniques He, Zhiwei Luo, Jiaying Lv, Mengna Li, Qingwen Ke, Wei Niu, Xuan Zhang, Zhaohui Front Neurol Neurology Atherosclerosis is an important cause of cerebrovascular and cardiovascular disease (CVD). Lipid infiltration, inflammation, and altered vascular stress are the critical mechanisms that cause atherosclerotic plaque formation. The hallmarks of the progression of atherosclerosis include plaque ulceration, rupture, neovascularization, and intraplaque hemorrhage, all of which are closely associated with the occurrence of CVD. Assessing the severity of atherosclerosis and plaque vulnerability is crucial for the prevention and treatment of CVD. Integrating imaging techniques for evaluating the characteristics of atherosclerotic plaques with computer simulations yields insights into plaque inflammation levels, spatial morphology, and intravascular stress distribution, resulting in a more realistic and accurate estimation of plaque state. Here, we review the characteristics and advancing techniques used to analyze intracranial and extracranial atherosclerotic plaques to provide a comprehensive understanding of atheroma. Frontiers Media S.A. 2023-10-12 /pmc/articles/PMC10603250/ /pubmed/37900593 http://dx.doi.org/10.3389/fneur.2023.1159288 Text en Copyright © 2023 He, Luo, Lv, Li, Ke, Niu and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
He, Zhiwei
Luo, Jiaying
Lv, Mengna
Li, Qingwen
Ke, Wei
Niu, Xuan
Zhang, Zhaohui
Characteristics and evaluation of atherosclerotic plaques: an overview of state-of-the-art techniques
title Characteristics and evaluation of atherosclerotic plaques: an overview of state-of-the-art techniques
title_full Characteristics and evaluation of atherosclerotic plaques: an overview of state-of-the-art techniques
title_fullStr Characteristics and evaluation of atherosclerotic plaques: an overview of state-of-the-art techniques
title_full_unstemmed Characteristics and evaluation of atherosclerotic plaques: an overview of state-of-the-art techniques
title_short Characteristics and evaluation of atherosclerotic plaques: an overview of state-of-the-art techniques
title_sort characteristics and evaluation of atherosclerotic plaques: an overview of state-of-the-art techniques
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603250/
https://www.ncbi.nlm.nih.gov/pubmed/37900593
http://dx.doi.org/10.3389/fneur.2023.1159288
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