Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy

Developmental and epileptic encephalopathies (DEEs) are severe seizure disorders with inadequate treatment options. Gain- or loss-of-function mutations of neuronal ion channel genes, including potassium channels and voltage-gated sodium channels, are common causes of DEE. We previously demonstrated...

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Detalles Bibliográficos
Autores principales: Hill, Sophie F., Jafar-Nejad, Paymaan, Rigo, Frank, Meisler, Miriam H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603267/
https://www.ncbi.nlm.nih.gov/pubmed/37901435
http://dx.doi.org/10.3389/fnins.2023.1282201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603267/
https://www.ncbi.nlm.nih.gov/pubmed/37901435
http://dx.doi.org/10.3389/fnins.2023.1282201

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