MCT4 blockade increases the efficacy of immune checkpoint blockade

BACKGROUND & AIMS: Intratumoral lactate accumulation and acidosis impair T-cell function and antitumor immunity. Interestingly, expression of the lactate transporter monocarboxylate transporter (MCT) 4, but not MCT1, turned out to be prognostic for the survival of patients with rectal cancer, in...

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Detalles Bibliográficos
Autores principales: Babl, Nathalie, Decking, Sonja-Maria, Voll, Florian, Althammer, Michael, Sala-Hojman, Ada, Ferretti, Roberta, Korf, Clarissa, Schmidl, Christian, Schmidleithner, Lisa, Nerb, Benedikt, Matos, Carina, Koehl, Gudrun E, Siska, Peter, Bruss, Christina, Kellermeier, Fabian, Dettmer, Katja, Oefner, Peter J, Wichland, Marvin, Ugele, Ines, Bohr, Christopher, Herr, Wolfgang, Ramaswamy, Shivapriya, Heinrich, Timo, Herhaus, Christian, Kreutz, Marina, Renner, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603342/
https://www.ncbi.nlm.nih.gov/pubmed/37880183
http://dx.doi.org/10.1136/jitc-2023-007349

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