Early Achromobacter xylosoxidans Endocarditis After the Valvular Mitral Replacement Complicated by an Agranulocytosis on B-lactams: A Case Report

An immunocompetent 82-year-old woman developed endocarditis caused by an atypical organism called Achromobacter xylosoxidans, after a first valvular surgery. The intravenous antibiotic therapy with ceftazidime - 2 g every 8 hours during five weeks - a key part of the treatment, induced agranulocytos...

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Detalles Bibliográficos
Autores principales: Channaoui, Aniss, Dubus, Michèle, Mathieu, Frédéric, Noirhomme, Séverine, Fontaine, Raphaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Cardiac/Thoracic/Vascular Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603368/
https://www.ncbi.nlm.nih.gov/pubmed/37900458
http://dx.doi.org/10.7759/cureus.46045
Descripción
Sumario:An immunocompetent 82-year-old woman developed endocarditis caused by an atypical organism called Achromobacter xylosoxidans, after a first valvular surgery. The intravenous antibiotic therapy with ceftazidime - 2 g every 8 hours during five weeks - a key part of the treatment, induced agranulocytosis as an adverse event. Cross-reactivity between antibiotics was suspected. Finally, the patient's cure was the result of a coordinated effort between medical and surgical professionals. Postoperative follow-up is six years.

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