Inhibition of SGK1 potentiates the anticancer activity of PI3K inhibitor in NSCLC cells through modulation of mTORC1, p‑ERK and β‑catenin signaling

Non-small cell lung cancer (NSCLC) is one of the deadliest types of cancer with poor prognosis, accounting for 85% of all lung cancer cases. The phosphoinositide 3-kinase (PI3K) signaling pathway is most frequently altered in NSCLC; nonetheless, targeting this pathway yields limited success primaril...

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Detalles Bibliográficos
Autores principales: Kale, Ramesh, Samant, Charudatt, Bokare, Anand, Verma, Mahip, Nandakumar, Krishnadas, Bhonde, Mandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603377/
https://www.ncbi.nlm.nih.gov/pubmed/37901878
http://dx.doi.org/10.3892/br.2023.1676

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