From mental strain to gut pain: A brain‐gut pathway transducing psychological stress to intestinal inflammation

Psychological stress can trigger inflammatory bowel disease (IBD) flares, but the molecular mechanisms have remained unclear. We recently discovered an unexpected function of the enteric nervous system as a relay between stress signals from the brain and intestinal inflammation. Our findings highlig...

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Detalles Bibliográficos
Autores principales: Schneider, Kai Markus, Blank, Niklas, Thaiss, Christoph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603380/
https://www.ncbi.nlm.nih.gov/pubmed/37885336
http://dx.doi.org/10.1002/ctm2.1458
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author Schneider, Kai Markus
Blank, Niklas
Thaiss, Christoph A.
author_facet Schneider, Kai Markus
Blank, Niklas
Thaiss, Christoph A.
author_sort Schneider, Kai Markus
collection PubMed
description Psychological stress can trigger inflammatory bowel disease (IBD) flares, but the molecular mechanisms have remained unclear. We recently discovered an unexpected function of the enteric nervous system as a relay between stress signals from the brain and intestinal inflammation. Our findings highlight targeting stress‐induced signaling networks as a possible new pillar in the clinical management of IBD.
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spelling pubmed-106033802023-10-28 From mental strain to gut pain: A brain‐gut pathway transducing psychological stress to intestinal inflammation Schneider, Kai Markus Blank, Niklas Thaiss, Christoph A. Clin Transl Med Commentary Psychological stress can trigger inflammatory bowel disease (IBD) flares, but the molecular mechanisms have remained unclear. We recently discovered an unexpected function of the enteric nervous system as a relay between stress signals from the brain and intestinal inflammation. Our findings highlight targeting stress‐induced signaling networks as a possible new pillar in the clinical management of IBD. John Wiley and Sons Inc. 2023-10-27 /pmc/articles/PMC10603380/ /pubmed/37885336 http://dx.doi.org/10.1002/ctm2.1458 Text en © 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Schneider, Kai Markus
Blank, Niklas
Thaiss, Christoph A.
From mental strain to gut pain: A brain‐gut pathway transducing psychological stress to intestinal inflammation
title From mental strain to gut pain: A brain‐gut pathway transducing psychological stress to intestinal inflammation
title_full From mental strain to gut pain: A brain‐gut pathway transducing psychological stress to intestinal inflammation
title_fullStr From mental strain to gut pain: A brain‐gut pathway transducing psychological stress to intestinal inflammation
title_full_unstemmed From mental strain to gut pain: A brain‐gut pathway transducing psychological stress to intestinal inflammation
title_short From mental strain to gut pain: A brain‐gut pathway transducing psychological stress to intestinal inflammation
title_sort from mental strain to gut pain: a brain‐gut pathway transducing psychological stress to intestinal inflammation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603380/
https://www.ncbi.nlm.nih.gov/pubmed/37885336
http://dx.doi.org/10.1002/ctm2.1458
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