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3D-Printed Flat-Bone-Mimetic Bioceramic Scaffolds for Cranial Restoration

The limitations of autologous bone grafts necessitate the development of advanced biomimetic biomaterials for efficient cranial defect restoration. The cranial bones are typical flat bones with sandwich structures, consisting of a diploe in the middle region and 2 outer compact tables. In this study...

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Detalles Bibliográficos
Autores principales: Zhang, Yihang, He, Fupo, Zhang, Qiang, Lu, Haotian, Yan, Shengtao, Shi, Xuetao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603392/
https://www.ncbi.nlm.nih.gov/pubmed/37899773
http://dx.doi.org/10.34133/research.0255
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author Zhang, Yihang
He, Fupo
Zhang, Qiang
Lu, Haotian
Yan, Shengtao
Shi, Xuetao
author_facet Zhang, Yihang
He, Fupo
Zhang, Qiang
Lu, Haotian
Yan, Shengtao
Shi, Xuetao
author_sort Zhang, Yihang
collection PubMed
description The limitations of autologous bone grafts necessitate the development of advanced biomimetic biomaterials for efficient cranial defect restoration. The cranial bones are typical flat bones with sandwich structures, consisting of a diploe in the middle region and 2 outer compact tables. In this study, we originally developed 2 types of flat-bone-mimetic β-tricalcium phosphate bioceramic scaffolds (Gyr-Comp and Gyr-Tub) by high-precision vat-photopolymerization-based 3-dimensional printing. Both scaffolds had 2 outer layers and an inner layer with gyroid pores mimicking the diploe structure. The outer layers of Gyr-Comp scaffolds simulated the low porosity of outer tables, while those of Gyr-Tub scaffolds mimicked the tubular pore structure in the tables of flat bones. The Gyr-Comp and Gyr-Tub scaffolds possessed higher compressive strength and noticeably promoted in vitro cell proliferation, osteogenic differentiation, and angiogenic activities compared with conventional scaffolds with cross-hatch structures. After implantation into rabbit cranial defects for 12 weeks, Gyr-Tub achieved the best repairing effects by accelerating the generation of bone tissues and blood vessels. This work provides an advanced strategy to prepare biomimetic biomaterials that fit the structural and functional needs of efficacious bone regeneration.
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spelling pubmed-106033922023-10-28 3D-Printed Flat-Bone-Mimetic Bioceramic Scaffolds for Cranial Restoration Zhang, Yihang He, Fupo Zhang, Qiang Lu, Haotian Yan, Shengtao Shi, Xuetao Research (Wash D C) Research Article The limitations of autologous bone grafts necessitate the development of advanced biomimetic biomaterials for efficient cranial defect restoration. The cranial bones are typical flat bones with sandwich structures, consisting of a diploe in the middle region and 2 outer compact tables. In this study, we originally developed 2 types of flat-bone-mimetic β-tricalcium phosphate bioceramic scaffolds (Gyr-Comp and Gyr-Tub) by high-precision vat-photopolymerization-based 3-dimensional printing. Both scaffolds had 2 outer layers and an inner layer with gyroid pores mimicking the diploe structure. The outer layers of Gyr-Comp scaffolds simulated the low porosity of outer tables, while those of Gyr-Tub scaffolds mimicked the tubular pore structure in the tables of flat bones. The Gyr-Comp and Gyr-Tub scaffolds possessed higher compressive strength and noticeably promoted in vitro cell proliferation, osteogenic differentiation, and angiogenic activities compared with conventional scaffolds with cross-hatch structures. After implantation into rabbit cranial defects for 12 weeks, Gyr-Tub achieved the best repairing effects by accelerating the generation of bone tissues and blood vessels. This work provides an advanced strategy to prepare biomimetic biomaterials that fit the structural and functional needs of efficacious bone regeneration. AAAS 2023-10-26 /pmc/articles/PMC10603392/ /pubmed/37899773 http://dx.doi.org/10.34133/research.0255 Text en Copyright © 2023 Yihang Zhang et al. https://creativecommons.org/licenses/by/4.0/Exclusive licensee Science and Technology Review Publishing House. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Zhang, Yihang
He, Fupo
Zhang, Qiang
Lu, Haotian
Yan, Shengtao
Shi, Xuetao
3D-Printed Flat-Bone-Mimetic Bioceramic Scaffolds for Cranial Restoration
title 3D-Printed Flat-Bone-Mimetic Bioceramic Scaffolds for Cranial Restoration
title_full 3D-Printed Flat-Bone-Mimetic Bioceramic Scaffolds for Cranial Restoration
title_fullStr 3D-Printed Flat-Bone-Mimetic Bioceramic Scaffolds for Cranial Restoration
title_full_unstemmed 3D-Printed Flat-Bone-Mimetic Bioceramic Scaffolds for Cranial Restoration
title_short 3D-Printed Flat-Bone-Mimetic Bioceramic Scaffolds for Cranial Restoration
title_sort 3d-printed flat-bone-mimetic bioceramic scaffolds for cranial restoration
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603392/
https://www.ncbi.nlm.nih.gov/pubmed/37899773
http://dx.doi.org/10.34133/research.0255
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