In Vivo Emergence of Pandrug-Resistant Acinetobacter baumannii Strain: Comprehensive Resistance Characterization and Compassionate Use of Sulbactam-Durlobactam

The treatment of patients with infection secondary to carbapenem-resistant Acinetobacter baumannii with emerging cefiderocol resistance remains challenging and unclear. We present a case of in vivo emergence of pandrug-resistant A baumannii that was successfully treated with the compassionate use of...

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Detalles Bibliográficos
Autores principales: VanNatta, Mollie, Grier, Laurie, Khan, Muhammad H, Pinargote Cornejo, Paulette, Alam, Mohammad, Moussa, Samir H, Smith, Jennifer G, Aitken, Samuel L, Malek, Alexandre E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603586/
https://www.ncbi.nlm.nih.gov/pubmed/37901122
http://dx.doi.org/10.1093/ofid/ofad504
Descripción
Sumario:The treatment of patients with infection secondary to carbapenem-resistant Acinetobacter baumannii with emerging cefiderocol resistance remains challenging and unclear. We present a case of in vivo emergence of pandrug-resistant A baumannii that was successfully treated with the compassionate use of investigational sulbactam-durlobactam–based antibiotic regimen. We also performed a longitudinal genomic analysis of the bacterial isolates and showed the development of resistance and genetic mutations over time.

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