In Vivo Emergence of Pandrug-Resistant Acinetobacter baumannii Strain: Comprehensive Resistance Characterization and Compassionate Use of Sulbactam-Durlobactam

The treatment of patients with infection secondary to carbapenem-resistant Acinetobacter baumannii with emerging cefiderocol resistance remains challenging and unclear. We present a case of in vivo emergence of pandrug-resistant A baumannii that was successfully treated with the compassionate use of...

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Autores principales: VanNatta, Mollie, Grier, Laurie, Khan, Muhammad H, Pinargote Cornejo, Paulette, Alam, Mohammad, Moussa, Samir H, Smith, Jennifer G, Aitken, Samuel L, Malek, Alexandre E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603586/
https://www.ncbi.nlm.nih.gov/pubmed/37901122
http://dx.doi.org/10.1093/ofid/ofad504
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author VanNatta, Mollie
Grier, Laurie
Khan, Muhammad H
Pinargote Cornejo, Paulette
Alam, Mohammad
Moussa, Samir H
Smith, Jennifer G
Aitken, Samuel L
Malek, Alexandre E
author_facet VanNatta, Mollie
Grier, Laurie
Khan, Muhammad H
Pinargote Cornejo, Paulette
Alam, Mohammad
Moussa, Samir H
Smith, Jennifer G
Aitken, Samuel L
Malek, Alexandre E
author_sort VanNatta, Mollie
collection PubMed
description The treatment of patients with infection secondary to carbapenem-resistant Acinetobacter baumannii with emerging cefiderocol resistance remains challenging and unclear. We present a case of in vivo emergence of pandrug-resistant A baumannii that was successfully treated with the compassionate use of investigational sulbactam-durlobactam–based antibiotic regimen. We also performed a longitudinal genomic analysis of the bacterial isolates and showed the development of resistance and genetic mutations over time.
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spelling pubmed-106035862023-10-28 In Vivo Emergence of Pandrug-Resistant Acinetobacter baumannii Strain: Comprehensive Resistance Characterization and Compassionate Use of Sulbactam-Durlobactam VanNatta, Mollie Grier, Laurie Khan, Muhammad H Pinargote Cornejo, Paulette Alam, Mohammad Moussa, Samir H Smith, Jennifer G Aitken, Samuel L Malek, Alexandre E Open Forum Infect Dis Brief Report The treatment of patients with infection secondary to carbapenem-resistant Acinetobacter baumannii with emerging cefiderocol resistance remains challenging and unclear. We present a case of in vivo emergence of pandrug-resistant A baumannii that was successfully treated with the compassionate use of investigational sulbactam-durlobactam–based antibiotic regimen. We also performed a longitudinal genomic analysis of the bacterial isolates and showed the development of resistance and genetic mutations over time. Oxford University Press 2023-10-06 /pmc/articles/PMC10603586/ /pubmed/37901122 http://dx.doi.org/10.1093/ofid/ofad504 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
VanNatta, Mollie
Grier, Laurie
Khan, Muhammad H
Pinargote Cornejo, Paulette
Alam, Mohammad
Moussa, Samir H
Smith, Jennifer G
Aitken, Samuel L
Malek, Alexandre E
In Vivo Emergence of Pandrug-Resistant Acinetobacter baumannii Strain: Comprehensive Resistance Characterization and Compassionate Use of Sulbactam-Durlobactam
title In Vivo Emergence of Pandrug-Resistant Acinetobacter baumannii Strain: Comprehensive Resistance Characterization and Compassionate Use of Sulbactam-Durlobactam
title_full In Vivo Emergence of Pandrug-Resistant Acinetobacter baumannii Strain: Comprehensive Resistance Characterization and Compassionate Use of Sulbactam-Durlobactam
title_fullStr In Vivo Emergence of Pandrug-Resistant Acinetobacter baumannii Strain: Comprehensive Resistance Characterization and Compassionate Use of Sulbactam-Durlobactam
title_full_unstemmed In Vivo Emergence of Pandrug-Resistant Acinetobacter baumannii Strain: Comprehensive Resistance Characterization and Compassionate Use of Sulbactam-Durlobactam
title_short In Vivo Emergence of Pandrug-Resistant Acinetobacter baumannii Strain: Comprehensive Resistance Characterization and Compassionate Use of Sulbactam-Durlobactam
title_sort in vivo emergence of pandrug-resistant acinetobacter baumannii strain: comprehensive resistance characterization and compassionate use of sulbactam-durlobactam
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603586/
https://www.ncbi.nlm.nih.gov/pubmed/37901122
http://dx.doi.org/10.1093/ofid/ofad504
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