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Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends

BACKGROUND: Worldwide, an estimated 4·4 million newborn deaths and stillbirths occurred in 2020, and 98% of these deaths occurred in low-income and middle-income countries (LMICs). We aimed to analyse new research grants for newborns and stillbirth awarded by major funders in 2019–20, and all resear...

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Autores principales: Agravat, Priyesh, Loucaides, Eva M, Kumar, Meghan Bruce, Howells, Anna, García, Alexandra Molina, Sebina, Ismail, Balanza, Núria, Fitchett, Elizabeth J A, Lawn, Joy E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603613/
https://www.ncbi.nlm.nih.gov/pubmed/37858589
http://dx.doi.org/10.1016/S2214-109X(23)00379-0
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author Agravat, Priyesh
Loucaides, Eva M
Kumar, Meghan Bruce
Howells, Anna
García, Alexandra Molina
Sebina, Ismail
Balanza, Núria
Fitchett, Elizabeth J A
Lawn, Joy E
author_facet Agravat, Priyesh
Loucaides, Eva M
Kumar, Meghan Bruce
Howells, Anna
García, Alexandra Molina
Sebina, Ismail
Balanza, Núria
Fitchett, Elizabeth J A
Lawn, Joy E
author_sort Agravat, Priyesh
collection PubMed
description BACKGROUND: Worldwide, an estimated 4·4 million newborn deaths and stillbirths occurred in 2020, and 98% of these deaths occurred in low-income and middle-income countries (LMICs). We aimed to analyse new research grants for newborns and stillbirth awarded by major funders in 2019–20, and all research funding allocated to LMIC-based institutions in 2011–20. METHODS: For this systematic analysis, we searched Dimensions, the world's largest research funding database, for grants relevant to neonatal and stillbirth research. Included grants were categorised by in-depth content analysis, with descriptive quantitative analyses by funder and recipient countries, research pipeline, topic, and year. FINDINGS: Globally, in 2019–20, major funders awarded a mean annual total of US$577·1 million per year for newborn and stillbirth research (mean total of 550 grants per year). $166·3 million (28·8%) of $577·1 million was directed to small and vulnerable newborn research, but only $8·4 million (1·5%) was directed to stillbirth research. The majority of funding, $537·0 million (93·0%), was allocated to organisations based in high-income countries. Between 2011 and 2020, LMIC-based recipients were named on 1985 grants from all funders worth $486·7 million, of which $73·1 million (15·0%) was allocated to small and vulnerable newborn research and $12·0 million (2·5%) was allocated to stillbirth research. Most LMIC funding supported preclinical or observational studies ($236·8 million [48·7%] of $486·7 million), with implementation research receiving only $13·9 million (2·9%). INTERPRETATION: Although investment in research related to neonatal health and stillbirths has increased between 2011 and 2020, there are marked disparities in distribution geographically, between major causes of mortality, and among research pipeline types. Stillbirth research received minimal funding in both high-income countries and LMICs, despite a similar number of deaths compared with neonates. Direct investment in LMIC-led research, especially for implementation research, could accelerate the slow global progress on stillbirth prevention and newborn survival. FUNDING: None. TRANSLATIONS: For the French, German and Spanish translations of the abstract see Supplementary Materials section.
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spelling pubmed-106036132023-10-28 Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends Agravat, Priyesh Loucaides, Eva M Kumar, Meghan Bruce Howells, Anna García, Alexandra Molina Sebina, Ismail Balanza, Núria Fitchett, Elizabeth J A Lawn, Joy E Lancet Glob Health Articles BACKGROUND: Worldwide, an estimated 4·4 million newborn deaths and stillbirths occurred in 2020, and 98% of these deaths occurred in low-income and middle-income countries (LMICs). We aimed to analyse new research grants for newborns and stillbirth awarded by major funders in 2019–20, and all research funding allocated to LMIC-based institutions in 2011–20. METHODS: For this systematic analysis, we searched Dimensions, the world's largest research funding database, for grants relevant to neonatal and stillbirth research. Included grants were categorised by in-depth content analysis, with descriptive quantitative analyses by funder and recipient countries, research pipeline, topic, and year. FINDINGS: Globally, in 2019–20, major funders awarded a mean annual total of US$577·1 million per year for newborn and stillbirth research (mean total of 550 grants per year). $166·3 million (28·8%) of $577·1 million was directed to small and vulnerable newborn research, but only $8·4 million (1·5%) was directed to stillbirth research. The majority of funding, $537·0 million (93·0%), was allocated to organisations based in high-income countries. Between 2011 and 2020, LMIC-based recipients were named on 1985 grants from all funders worth $486·7 million, of which $73·1 million (15·0%) was allocated to small and vulnerable newborn research and $12·0 million (2·5%) was allocated to stillbirth research. Most LMIC funding supported preclinical or observational studies ($236·8 million [48·7%] of $486·7 million), with implementation research receiving only $13·9 million (2·9%). INTERPRETATION: Although investment in research related to neonatal health and stillbirths has increased between 2011 and 2020, there are marked disparities in distribution geographically, between major causes of mortality, and among research pipeline types. Stillbirth research received minimal funding in both high-income countries and LMICs, despite a similar number of deaths compared with neonates. Direct investment in LMIC-led research, especially for implementation research, could accelerate the slow global progress on stillbirth prevention and newborn survival. FUNDING: None. TRANSLATIONS: For the French, German and Spanish translations of the abstract see Supplementary Materials section. Elsevier Ltd 2023-10-17 /pmc/articles/PMC10603613/ /pubmed/37858589 http://dx.doi.org/10.1016/S2214-109X(23)00379-0 Text en © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Articles
Agravat, Priyesh
Loucaides, Eva M
Kumar, Meghan Bruce
Howells, Anna
García, Alexandra Molina
Sebina, Ismail
Balanza, Núria
Fitchett, Elizabeth J A
Lawn, Joy E
Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends
title Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends
title_full Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends
title_fullStr Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends
title_full_unstemmed Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends
title_short Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends
title_sort research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603613/
https://www.ncbi.nlm.nih.gov/pubmed/37858589
http://dx.doi.org/10.1016/S2214-109X(23)00379-0
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