Rational Screening for Cooperativity in Small-Molecule Inducers of Protein–Protein Associations

[Image: see text] The hallmark of a molecular glue is its ability to induce cooperative protein–protein interactions, leading to the formation of a ternary complex, despite weaker binding toward one or both individual proteins. Notably, the extent of cooperativity distinguishes molecular glues from...

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Detalles Bibliográficos
Autores principales: Liu, Shuang, Tong, Bingqi, Mason, Jeremy W., Ostrem, Jonathan M., Tutter, Antonin, Hua, Bruce K., Tang, Sunny A., Bonazzi, Simone, Briner, Karin, Berst, Frédéric, Zécri, Frédéric J., Schreiber, Stuart L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603787/
https://www.ncbi.nlm.nih.gov/pubmed/37816014
http://dx.doi.org/10.1021/jacs.3c08307

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