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Obesity-Associated Non-T2 Mechanisms in Obese Asthmatic Individuals
Obesity and asthma are two common health issues that have shown increased prevalence in recent years and have become a significant socioeconomic burden worldwide. Obesity increases asthma incidence and severity. Obese asthmatic individuals often experience increased exacerbation rates, enhanced airw...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603840/ https://www.ncbi.nlm.nih.gov/pubmed/37893170 http://dx.doi.org/10.3390/biomedicines11102797 |
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author | Shailesh, Harshita Bhat, Ajaz A. Janahi, Ibrahim A. |
author_facet | Shailesh, Harshita Bhat, Ajaz A. Janahi, Ibrahim A. |
author_sort | Shailesh, Harshita |
collection | PubMed |
description | Obesity and asthma are two common health issues that have shown increased prevalence in recent years and have become a significant socioeconomic burden worldwide. Obesity increases asthma incidence and severity. Obese asthmatic individuals often experience increased exacerbation rates, enhanced airway remodeling, and reduced response to standard corticosteroid therapy. Recent studies indicate that obesity-associated non-T2 factors such as mechanical stress, hyperinsulinemia, systemic inflammation, adipose tissue mediators, metabolic dysregulation, microbiome dysbiosis, and high-fat-diet are responsible for increased asthma symptoms and reduced therapeutic response in obese asthmatic individuals. This manuscript reviews the recent findings highlighting the role of obesity-associated factors that contribute to airway hyper-reactivity, airway inflammation and remodeling, and immune cell dysfunction, consequently contributing to worsening asthma symptoms. Furthermore, the review also discusses the possible future therapies that might play a role in reducing asthma symptoms by diminishing the impact of obesity-associated non-T2 factors. |
format | Online Article Text |
id | pubmed-10603840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106038402023-10-28 Obesity-Associated Non-T2 Mechanisms in Obese Asthmatic Individuals Shailesh, Harshita Bhat, Ajaz A. Janahi, Ibrahim A. Biomedicines Review Obesity and asthma are two common health issues that have shown increased prevalence in recent years and have become a significant socioeconomic burden worldwide. Obesity increases asthma incidence and severity. Obese asthmatic individuals often experience increased exacerbation rates, enhanced airway remodeling, and reduced response to standard corticosteroid therapy. Recent studies indicate that obesity-associated non-T2 factors such as mechanical stress, hyperinsulinemia, systemic inflammation, adipose tissue mediators, metabolic dysregulation, microbiome dysbiosis, and high-fat-diet are responsible for increased asthma symptoms and reduced therapeutic response in obese asthmatic individuals. This manuscript reviews the recent findings highlighting the role of obesity-associated factors that contribute to airway hyper-reactivity, airway inflammation and remodeling, and immune cell dysfunction, consequently contributing to worsening asthma symptoms. Furthermore, the review also discusses the possible future therapies that might play a role in reducing asthma symptoms by diminishing the impact of obesity-associated non-T2 factors. MDPI 2023-10-16 /pmc/articles/PMC10603840/ /pubmed/37893170 http://dx.doi.org/10.3390/biomedicines11102797 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shailesh, Harshita Bhat, Ajaz A. Janahi, Ibrahim A. Obesity-Associated Non-T2 Mechanisms in Obese Asthmatic Individuals |
title | Obesity-Associated Non-T2 Mechanisms in Obese Asthmatic Individuals |
title_full | Obesity-Associated Non-T2 Mechanisms in Obese Asthmatic Individuals |
title_fullStr | Obesity-Associated Non-T2 Mechanisms in Obese Asthmatic Individuals |
title_full_unstemmed | Obesity-Associated Non-T2 Mechanisms in Obese Asthmatic Individuals |
title_short | Obesity-Associated Non-T2 Mechanisms in Obese Asthmatic Individuals |
title_sort | obesity-associated non-t2 mechanisms in obese asthmatic individuals |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603840/ https://www.ncbi.nlm.nih.gov/pubmed/37893170 http://dx.doi.org/10.3390/biomedicines11102797 |
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