Spike Protein Mutation-Induced Changes in the Kinetic and Thermodynamic Behavior of Its Receptor Binding Domains Explain Their Higher Propensity to Attain Open States in SARS-CoV-2 Variants of Concern

[Image: see text] Spike (S) protein opening in SARS-CoV-2 controls the accessibility of its receptor binding domains (RBDs) to host receptors and immune recognition. Along the evolution of SARS-CoV-2 to its variants of concern (VOC)—alpha, beta, gamma, delta, and omicron—their S proteins showed a hi...

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Detalles Bibliográficos
Autores principales: Singh, Jasdeep, Vashishtha, Shubham, Kundu, Bishwajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604015/
https://www.ncbi.nlm.nih.gov/pubmed/37901170
http://dx.doi.org/10.1021/acscentsci.3c00810

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