Monoclonal Antibody Disrupts Biofilm Structure and Restores Antibiotic Susceptibility in an Orthopedic Implant Infection Model

Bacterial biofilms on orthopedic implants are resistant to the host immune response and to traditional systemic antibiotics. Novel therapies are needed to improve patient outcomes. TRL1068 is a human monoclonal antibody (mAb) against a biofilm anchoring protein. For assessment of this agent in an or...

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Detalles Bibliográficos
Autores principales: Burke, Zachary D. C., Hart, Christopher M., Kelley, Benjamin V., Mamouei, Zeinab, Blumstein, Gideon W., Hamad, Christopher, Hori, Kellyn, Cevallos, Nicolas, Villalpando, Christina, Truong, Nicole, Turkmani, Amr, Ralston, Micah, Kavanaugh, Aaron, Tenorio, Edgar, Kauvar, Lawrence M., Li, Alan, Prunet, Nathanael, Stavrakis, Alexandra I., Bernthal, Nicholas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604051/
https://www.ncbi.nlm.nih.gov/pubmed/37887191
http://dx.doi.org/10.3390/antibiotics12101490

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