Cargando…

Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies

SIMPLE SUMMARY: The accumulation of senescent cells is now widely known to be a driver of aging and many age-related pathologies, such as neurodegeneration and type 2 diabetes, among others. Targeting senescent cells for selective removal or altering the proteins they release are promising therapeut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dey, Amit K., Banarjee, Reema, Boroumand, Mozhgan, Rutherford, Delaney V., Strassheim, Quinn, Nyunt, Thedoe, Olinger, Bradley, Basisty, Nathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604147/ https://www.ncbi.nlm.nih.gov/pubmed/37887011 http://dx.doi.org/10.3390/biology12101301

Ejemplares similares

Senotherapeutics in Cancer and HIV
por: Sánchez-Díaz, Laura, et al.
Publicado: (2022)

The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets
por: Rossi, Martina, et al.
Publicado: (2021)

Quantification and Identification of Post-Translational Modifications Using Modern Proteomics Approaches
por: Holtz, Anja, et al.
Publicado: (2021)

Senotherapeutics and Their Molecular Mechanism for Improving Aging
por: Park, Jooho, et al.
Publicado: (2022)

Senotherapeutics: emerging strategy for healthy aging and age-related disease
por: Kim, Eok-Cheon, et al.
Publicado: (2019)

Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly
por: Li, Zhiqiang, et al.
Publicado: (2023)

Fisetin is a senotherapeutic that extends health and lifespan
por: Yousefzadeh, Matthew J., et al.
Publicado: (2018)

Senotherapeutic Effect of Retinaldehyde and Hyaluronate Fragments in Dermatoporosis
por: Kaya, Aysin, et al.
Publicado: (2023)

In vitro and in vivo toxicity assessment of the senotherapeutic Peptide 14
por: Zonari, Alessandra, et al.
Publicado: (2022)

Targeting cellular senescence with novel senotherapeutics by design to extend healthspan
por: Zhang, Lei, et al.
Publicado: (2021)

Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics
por: Bulbiankova, Darya, et al.
Publicado: (2023)

The role of cellular senescence in metabolic diseases and the potential for senotherapeutic interventions
por: Zhang, Huantong, et al.
Publicado: (2023)

Senotherapeutics: a possible mitigator of age-related pulmonary disease
por: eBioMedicine
Publicado: (2023)

COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine?
por: Hipkiss, Alan R
Publicado: (2020)

Senotherapeutic drugs for human intervertebral disc degeneration and low back pain
por: Cherif, Hosni, et al.
Publicado: (2020)

The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions
por: Secomandi, Laura, et al.
Publicado: (2021)

Potential Role of Polyphenolic Flavonoids as Senotherapeutic Agents in Degenerative Diseases and Geroprotection
por: Mbara, Kingsley C., et al.
Publicado: (2022)

FUCOIDANS ARE NOVEL SENOTHERAPEUTICS THAT ENHANCE SIRT6 AND DNA REPAIR ACTIVITY
por: Zhang, Lei, et al.
Publicado: (2022)

FUCOIDANS ARE NOVEL SENOTHERAPEUTICS THAT ENHANCE SIRT6 AND DNA REPAIR ACTIVITY
por: Zhang, Lei, et al.
Publicado: (2022)

Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics
por: Han, Yeaeun, et al.
Publicado: (2023)

Proteomics in aging research: A roadmap to clinical, translational research
por: Moaddel, Ruin, et al.
Publicado: (2021)

Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and Senotherapeutic Potential
por: Rivera-Torres, José, et al.
Publicado: (2019)

The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice
por: Xu, Qixia, et al.
Publicado: (2021)

Drugs against metabolic diseases as potential senotherapeutics for aging-related respiratory diseases
por: Matsubayashi, Sachi, et al.
Publicado: (2023)

The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice
por: Yoshida, Shota, et al.
Publicado: (2020)

Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection
por: Elsallabi, Osama, et al.
Publicado: (2022)

Senotherapeutic-like effect of Silybum marianum flower extract revealed on human skin cells
por: Woo, Jieun, et al.
Publicado: (2021)

Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models
por: Zonari, Alessandra, et al.
Publicado: (2023)

Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health Threats
por: Malavolta, Marco, et al.
Publicado: (2020)

Senescence in HBV-, HCV- and NAFLD- Mediated Hepatocellular Carcinoma and Senotherapeutics: Current Evidence and Future Perspective
por: Giannakoulis, Vassilis G., et al.
Publicado: (2021)

Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β Cells
por: Murakami, Takaaki, et al.
Publicado: (2022)

The senotherapeutic nicotinamide riboside raises platelet nicotinamide adenine dinucleotide levels but cannot prevent storage lesion
por: Delabie, Willem, et al.
Publicado: (2019)

The Ercc1(-/Δ) mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions
por: Wong, Alec, et al.
Publicado: (2020)

Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
por: Alessio, Nicola, et al.
Publicado: (2021)

The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice
por: Ritschka, Birgit, et al.
Publicado: (2020)

Quantitative Proteomic Analysis of the Senescence‐Associated Secretory Phenotype by Data‐Independent Acquisition
por: Neri, Francesco, et al.
Publicado: (2021)

The translational activator Sov1 coordinates mitochondrial gene expression with mitoribosome biogenesis
por: Seshadri, Suhas R, et al.
Publicado: (2020)

Meta-analysis of senescent cell secretomes to identify common and specific features of the different senescent phenotypes: a tool for developing new senotherapeutics
por: Oguma, Yo, et al.
Publicado: (2023)

Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions
por: Christensen, David G., et al.
Publicado: (2019)

Plasma proteomic biomarker signature of age predicts health and life span
por: Tanaka, Toshiko, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_m7a6t2ab76rioa1bbjc5ceog8p