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Bedside Hyperspectral Imaging and Organ Dysfunction Severity in Critically Ill COVID-19 Patients—A Prospective, Monocentric Observational Study
Hyperspectral imaging (HSI) is a non-invasive technology that provides information on biochemical tissue properties, including skin oxygenation and perfusion quality. Microcirculatory alterations are associated with organ dysfunction in septic COVID-19 patients. This prospective observational study...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604239/ https://www.ncbi.nlm.nih.gov/pubmed/37892897 http://dx.doi.org/10.3390/bioengineering10101167 |
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author | Kuhlmann, Henning Garczarek, Lena Künne, David Pattberg, Kevin Skarabis, Annabell Frank, Mirjam Schmidt, Börge Arends, Sven Herbstreit, Frank Brenner, Thorsten Schmidt, Karsten Espeter, Florian |
author_facet | Kuhlmann, Henning Garczarek, Lena Künne, David Pattberg, Kevin Skarabis, Annabell Frank, Mirjam Schmidt, Börge Arends, Sven Herbstreit, Frank Brenner, Thorsten Schmidt, Karsten Espeter, Florian |
author_sort | Kuhlmann, Henning |
collection | PubMed |
description | Hyperspectral imaging (HSI) is a non-invasive technology that provides information on biochemical tissue properties, including skin oxygenation and perfusion quality. Microcirculatory alterations are associated with organ dysfunction in septic COVID-19 patients. This prospective observational study investigated associations between skin HSI and organ dysfunction severity in critically ill COVID-19 patients. During the first seven days in the ICU, palmar HSI measurements were carried out with the TIVITA(®) tissue system. We report data from 52 critically ill COVID-19 patients, of whom 40 required extracorporeal membrane oxygenation (ECMO). HSI parameters for superficial tissue oxygenation (StO(2)) and oxygenation and perfusion quality (NPI) were persistently decreased. Hemoglobin tissue content (THI) increased, and tissue water content (TWI) was persistently elevated. Regression analysis showed strong indications for an association of NPI and weaker indications for associations of StO(2), THI, and TWI with sequential organ failure assessment (SOFA) scoring. StO(2) and NPI demonstrated negative associations with vasopressor support and lactate levels as well as positive associations with arterial oxygen saturation. These results suggest that skin HSI provides clinically relevant information, opening new perspectives for microcirculatory monitoring in critical care. |
format | Online Article Text |
id | pubmed-10604239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106042392023-10-28 Bedside Hyperspectral Imaging and Organ Dysfunction Severity in Critically Ill COVID-19 Patients—A Prospective, Monocentric Observational Study Kuhlmann, Henning Garczarek, Lena Künne, David Pattberg, Kevin Skarabis, Annabell Frank, Mirjam Schmidt, Börge Arends, Sven Herbstreit, Frank Brenner, Thorsten Schmidt, Karsten Espeter, Florian Bioengineering (Basel) Article Hyperspectral imaging (HSI) is a non-invasive technology that provides information on biochemical tissue properties, including skin oxygenation and perfusion quality. Microcirculatory alterations are associated with organ dysfunction in septic COVID-19 patients. This prospective observational study investigated associations between skin HSI and organ dysfunction severity in critically ill COVID-19 patients. During the first seven days in the ICU, palmar HSI measurements were carried out with the TIVITA(®) tissue system. We report data from 52 critically ill COVID-19 patients, of whom 40 required extracorporeal membrane oxygenation (ECMO). HSI parameters for superficial tissue oxygenation (StO(2)) and oxygenation and perfusion quality (NPI) were persistently decreased. Hemoglobin tissue content (THI) increased, and tissue water content (TWI) was persistently elevated. Regression analysis showed strong indications for an association of NPI and weaker indications for associations of StO(2), THI, and TWI with sequential organ failure assessment (SOFA) scoring. StO(2) and NPI demonstrated negative associations with vasopressor support and lactate levels as well as positive associations with arterial oxygen saturation. These results suggest that skin HSI provides clinically relevant information, opening new perspectives for microcirculatory monitoring in critical care. MDPI 2023-10-06 /pmc/articles/PMC10604239/ /pubmed/37892897 http://dx.doi.org/10.3390/bioengineering10101167 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kuhlmann, Henning Garczarek, Lena Künne, David Pattberg, Kevin Skarabis, Annabell Frank, Mirjam Schmidt, Börge Arends, Sven Herbstreit, Frank Brenner, Thorsten Schmidt, Karsten Espeter, Florian Bedside Hyperspectral Imaging and Organ Dysfunction Severity in Critically Ill COVID-19 Patients—A Prospective, Monocentric Observational Study |
title | Bedside Hyperspectral Imaging and Organ Dysfunction Severity in Critically Ill COVID-19 Patients—A Prospective, Monocentric Observational Study |
title_full | Bedside Hyperspectral Imaging and Organ Dysfunction Severity in Critically Ill COVID-19 Patients—A Prospective, Monocentric Observational Study |
title_fullStr | Bedside Hyperspectral Imaging and Organ Dysfunction Severity in Critically Ill COVID-19 Patients—A Prospective, Monocentric Observational Study |
title_full_unstemmed | Bedside Hyperspectral Imaging and Organ Dysfunction Severity in Critically Ill COVID-19 Patients—A Prospective, Monocentric Observational Study |
title_short | Bedside Hyperspectral Imaging and Organ Dysfunction Severity in Critically Ill COVID-19 Patients—A Prospective, Monocentric Observational Study |
title_sort | bedside hyperspectral imaging and organ dysfunction severity in critically ill covid-19 patients—a prospective, monocentric observational study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604239/ https://www.ncbi.nlm.nih.gov/pubmed/37892897 http://dx.doi.org/10.3390/bioengineering10101167 |
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