Cargando…

Regulation of Protein-Induced Apoptosis and Autophagy in Human Hepatocytes Treated with Metformin and Paclitaxel In Silico and In Vitro

Metformin and paclitaxel therapy offer promising outcomes in the treatment of liver cancer. Combining paclitaxel with metformin enhances treatment effectiveness and mitigates the adverse effects associated with paclitaxel alone. This study explored the anticancer properties of metformin and paclitax...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Zahrani, Norah Saeed, Zamzami, Mazin Abdulaziz, Baghdadi, Mohammed A., El-Gowily, Afnan H., Ali, Ehab M. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604243/ https://www.ncbi.nlm.nih.gov/pubmed/37893061 http://dx.doi.org/10.3390/biomedicines11102688

Ejemplares similares

Potential antiviral properties of antiplatelet agents against SARS-CoV-2 infection: an in silico perspective
por: Abosheasha, Mohammed A., et al.
Publicado: (2021)

Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells
por: El-Gowily, Afnan H., et al.
Publicado: (2021)

Metformin Protects Rat Hepatocytes against Bile Acid-Induced Apoptosis
por: Woudenberg-Vrenken, Titia E., et al.
Publicado: (2013)

Autophagy protects against palmitate-induced apoptosis in hepatocytes
por: Cai, Ning, et al.
Publicado: (2014)

Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells
por: Alzahrani, Abdulaziz Musa, et al.
Publicado: (2021)

Metformin protects primary rat hepatocytes against oxidative stress-induced apoptosis
por: de la Rosa, Laura Conde, et al.
Publicado: (2015)

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms
por: Tomic, T, et al.
Publicado: (2011)

The effect of paclitaxel on apoptosis, autophagy and mitotic catastrophe in AGS cells
por: Khing, Tin Myo, et al.
Publicado: (2021)

Levosimendan Inhibits Peroxidation in Hepatocytes by Modulating Apoptosis/Autophagy Interplay
por: Grossini, Elena, et al.
Publicado: (2015)

Recombinant l-glutaminase obtained from Geobacillus thermodenitrificans DSM-465: characterization and in silico elucidation of conserved structural domains
por: Shah, Luqman, et al.
Publicado: (2019)

Effect of metformin on the proliferation, apoptosis, invasion and autophagy of ovarian cancer cells
por: Zou, Ge, et al.
Publicado: (2019)

T-2 Toxin Induces Oxidative Stress, Apoptosis and Cytoprotective Autophagy in Chicken Hepatocytes
por: Yin, Huadong, et al.
Publicado: (2020)

Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway
por: Tsai, Hsin-Hwa, et al.
Publicado: (2017)

Modulation of autophagy, apoptosis and oxidative stress: a clue for repurposing metformin in photoaging
por: Mostafa, Dalia Kamal, et al.
Publicado: (2022)

Metformin Stimulates FGF21 Expression in Primary Hepatocytes
por: Nygaard, Eva B., et al.
Publicado: (2012)

Inosine Triphosphate Pyrophosphatase (ITPase): Functions, Mutations, Polymorphisms and Its Impact on Cancer Therapies
por: Zamzami, Mazin A.
Publicado: (2022)

Preparation of 6-Mercaptopurine Loaded Liposomal Formulation for Enhanced Cytotoxic Response in Cancer Cells
por: Jamal, Alam, et al.
Publicado: (2022)

Mechanism of Hepatocyte Apoptosis
por: Cao, Lei, et al.
Publicado: (2016)

Metformin induces autophagy of cisplatin-resistant human gastric cancer cells in addition to apoptosis
por: Fang, Chih-Wun, et al.
Publicado: (2023)

Compound C, a Broad Kinase Inhibitor Alters Metabolic Fingerprinting of Extra Cellular Matrix Detached Cancer Cells
por: Shait Mohammed, Mohammed Razeeth, et al.
Publicado: (2021)

Inhibition of FOXO1-mediated autophagy promotes paclitaxel-induced apoptosis of MDA-MB-231 cells
por: Xu, Kaixiang, et al.
Publicado: (2022)

Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling
por: Feng, Y, et al.
Publicado: (2014)

Metformin suppresses inflammation and apoptosis of myocardiocytes by inhibiting autophagy in a model of ischemia-reperfusion injury
por: Huang, Kai-yu, et al.
Publicado: (2020)

Albumin Paclitaxel Compared with 5-Penfluorouracil, Lobaplatin, and Albumin Paclitaxel Combined with 5-Penfluorouracil in the Treatment of Human Gastric Cancer Cell AGS Line Autophagy and Apoptosis
por: Cheng, Xingzhen, et al.
Publicado: (2022)

In Silico Inference of Synthetic Cytotoxic Interactions from Paclitaxel Responses
por: Lee, Jeong Hoon, et al.
Publicado: (2021)

Camellia nitidissima Chi Extract Potentiates the Sensitivity of Gastric Cancer Cells to Paclitaxel via the Induction of Autophagy and Apoptosis
por: He, Xu, et al.
Publicado: (2019)

Direct lysosome-based autophagy of lipid droplets in hepatocytes
por: Schulze, Ryan J., et al.
Publicado: (2020)

Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells
por: Jiménez-Guerrero, Rocío, et al.
Publicado: (2018)

Metformin impairs growth of endometrial cancer cells via cell cycle arrest and concomitant autophagy and apoptosis
por: Takahashi, Akimasa, et al.
Publicado: (2014)

Metformin Promotes Apoptosis but Suppresses Autophagy in Glucose-Deprived H4IIE Hepatocellular Carcinoma Cells
por: Park, Deok-Bae
Publicado: (2015)

Synergistic Enhancement of Paclitaxel-induced Inhibition of Cell Growth by Metformin in Melanoma Cells
por: Ko, Gihyun, et al.
Publicado: (2019)

Atg9b Deficiency Suppresses Autophagy and Potentiates Endoplasmic Reticulum Stress-Associated Hepatocyte Apoptosis in Hepatocarcinogenesis
por: Wang, Ning, et al.
Publicado: (2017)

Vitamin D Receptor Activation Targets ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Hepatocytes in Cholestasic Mice
por: Zheng, Zhijian, et al.
Publicado: (2022)

Combination of metformin and paclitaxel suppresses proliferation and induces apoptosis of human prostate cancer cells via oxidative stress and targeting the mitochondria-dependent pathway
por: Zhao, Yuwan, et al.
Publicado: (2019)

Metformin inhibits spontaneous excitatory postsynaptic currents in spinal dorsal cord neurons from paclitaxel-treated rats
por: Liu, Ting-Ting, et al.
Publicado: (2023)

Thymoquinone and Difluoromethylornithine (DFMO) Synergistically Induce Apoptosis of Human Acute T Lymphoblastic Leukemia Jurkat Cells Through the Modulation of Epigenetic Pathways
por: Alhosin, Mahmoud, et al.
Publicado: (2020)

Biological and clinical significance of the glypican-3 gene in human lung adenocarcinoma: An in silico analysis
por: Imon, Raihan Rahman, et al.
Publicado: (2023)

A case of recurrent metastatic ameloblastoma and hypercalcaemia successfully treated with carboplatin and paclitaxel: long survival and prolonged stable disease
por: Ghiam, AF, et al.
Publicado: (2013)

Activation of autophagy flux by metformin downregulates cellular FLICE–like inhibitory protein and enhances TRAIL- induced apoptosis
por: Nazim, Uddin MD, et al.
Publicado: (2016)

Metformin Triggers Autophagy to Attenuate Drug-Induced Apoptosis in NSCLC Cells, with Minor Effects on Tumors of Diabetic Patients
por: Xiao, Zhiguang, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_87p2441ucc2d8d267gportm60h