Cargando…

Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes

Cardiovascular diseases and diabetes mellitus are currently among the diseases with the highest morbidity and mortality. The pathogenesis and development of these diseases remain strongly connected, along with inflammation playing a major role. Therefore, the treatment possibilities showing a positi...

Descripción completa

Detalles Bibliográficos
Autores principales: Tokarek, Julita, Budny, Emilian, Saar, Maciej, Stańczak, Kamila, Wojtanowska, Ewa, Młynarska, Ewelina, Rysz, Jacek, Franczyk, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604380/
https://www.ncbi.nlm.nih.gov/pubmed/37892985
http://dx.doi.org/10.3390/biomedicines11102611
_version_ 1785126821686149120
author Tokarek, Julita
Budny, Emilian
Saar, Maciej
Stańczak, Kamila
Wojtanowska, Ewa
Młynarska, Ewelina
Rysz, Jacek
Franczyk, Beata
author_facet Tokarek, Julita
Budny, Emilian
Saar, Maciej
Stańczak, Kamila
Wojtanowska, Ewa
Młynarska, Ewelina
Rysz, Jacek
Franczyk, Beata
author_sort Tokarek, Julita
collection PubMed
description Cardiovascular diseases and diabetes mellitus are currently among the diseases with the highest morbidity and mortality. The pathogenesis and development of these diseases remain strongly connected, along with inflammation playing a major role. Therefore, the treatment possibilities showing a positive impact on both of these diseases could be especially beneficial for patients. SGLT-2 inhibitors and GLP-1 receptor agonists present this dual effect. Moreover, the hostile composition of the gut microbiota could influence the progression of these conditions. In this review, the authors present the latest knowledge on and innovations in diabetes mellitus and CVD—with the focus on the molecular mechanisms and the role of the microbiota.
format Online
Article
Text
id pubmed-10604380
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106043802023-10-28 Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes Tokarek, Julita Budny, Emilian Saar, Maciej Stańczak, Kamila Wojtanowska, Ewa Młynarska, Ewelina Rysz, Jacek Franczyk, Beata Biomedicines Review Cardiovascular diseases and diabetes mellitus are currently among the diseases with the highest morbidity and mortality. The pathogenesis and development of these diseases remain strongly connected, along with inflammation playing a major role. Therefore, the treatment possibilities showing a positive impact on both of these diseases could be especially beneficial for patients. SGLT-2 inhibitors and GLP-1 receptor agonists present this dual effect. Moreover, the hostile composition of the gut microbiota could influence the progression of these conditions. In this review, the authors present the latest knowledge on and innovations in diabetes mellitus and CVD—with the focus on the molecular mechanisms and the role of the microbiota. MDPI 2023-09-23 /pmc/articles/PMC10604380/ /pubmed/37892985 http://dx.doi.org/10.3390/biomedicines11102611 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tokarek, Julita
Budny, Emilian
Saar, Maciej
Stańczak, Kamila
Wojtanowska, Ewa
Młynarska, Ewelina
Rysz, Jacek
Franczyk, Beata
Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes
title Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes
title_full Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes
title_fullStr Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes
title_full_unstemmed Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes
title_short Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes
title_sort molecular processes involved in the shared pathways between cardiovascular diseases and diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604380/
https://www.ncbi.nlm.nih.gov/pubmed/37892985
http://dx.doi.org/10.3390/biomedicines11102611
work_keys_str_mv AT tokarekjulita molecularprocessesinvolvedinthesharedpathwaysbetweencardiovasculardiseasesanddiabetes
AT budnyemilian molecularprocessesinvolvedinthesharedpathwaysbetweencardiovasculardiseasesanddiabetes
AT saarmaciej molecularprocessesinvolvedinthesharedpathwaysbetweencardiovasculardiseasesanddiabetes
AT stanczakkamila molecularprocessesinvolvedinthesharedpathwaysbetweencardiovasculardiseasesanddiabetes
AT wojtanowskaewa molecularprocessesinvolvedinthesharedpathwaysbetweencardiovasculardiseasesanddiabetes
AT młynarskaewelina molecularprocessesinvolvedinthesharedpathwaysbetweencardiovasculardiseasesanddiabetes
AT ryszjacek molecularprocessesinvolvedinthesharedpathwaysbetweencardiovasculardiseasesanddiabetes
AT franczykbeata molecularprocessesinvolvedinthesharedpathwaysbetweencardiovasculardiseasesanddiabetes