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Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes
Cardiovascular diseases and diabetes mellitus are currently among the diseases with the highest morbidity and mortality. The pathogenesis and development of these diseases remain strongly connected, along with inflammation playing a major role. Therefore, the treatment possibilities showing a positi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604380/ https://www.ncbi.nlm.nih.gov/pubmed/37892985 http://dx.doi.org/10.3390/biomedicines11102611 |
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author | Tokarek, Julita Budny, Emilian Saar, Maciej Stańczak, Kamila Wojtanowska, Ewa Młynarska, Ewelina Rysz, Jacek Franczyk, Beata |
author_facet | Tokarek, Julita Budny, Emilian Saar, Maciej Stańczak, Kamila Wojtanowska, Ewa Młynarska, Ewelina Rysz, Jacek Franczyk, Beata |
author_sort | Tokarek, Julita |
collection | PubMed |
description | Cardiovascular diseases and diabetes mellitus are currently among the diseases with the highest morbidity and mortality. The pathogenesis and development of these diseases remain strongly connected, along with inflammation playing a major role. Therefore, the treatment possibilities showing a positive impact on both of these diseases could be especially beneficial for patients. SGLT-2 inhibitors and GLP-1 receptor agonists present this dual effect. Moreover, the hostile composition of the gut microbiota could influence the progression of these conditions. In this review, the authors present the latest knowledge on and innovations in diabetes mellitus and CVD—with the focus on the molecular mechanisms and the role of the microbiota. |
format | Online Article Text |
id | pubmed-10604380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106043802023-10-28 Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes Tokarek, Julita Budny, Emilian Saar, Maciej Stańczak, Kamila Wojtanowska, Ewa Młynarska, Ewelina Rysz, Jacek Franczyk, Beata Biomedicines Review Cardiovascular diseases and diabetes mellitus are currently among the diseases with the highest morbidity and mortality. The pathogenesis and development of these diseases remain strongly connected, along with inflammation playing a major role. Therefore, the treatment possibilities showing a positive impact on both of these diseases could be especially beneficial for patients. SGLT-2 inhibitors and GLP-1 receptor agonists present this dual effect. Moreover, the hostile composition of the gut microbiota could influence the progression of these conditions. In this review, the authors present the latest knowledge on and innovations in diabetes mellitus and CVD—with the focus on the molecular mechanisms and the role of the microbiota. MDPI 2023-09-23 /pmc/articles/PMC10604380/ /pubmed/37892985 http://dx.doi.org/10.3390/biomedicines11102611 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tokarek, Julita Budny, Emilian Saar, Maciej Stańczak, Kamila Wojtanowska, Ewa Młynarska, Ewelina Rysz, Jacek Franczyk, Beata Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes |
title | Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes |
title_full | Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes |
title_fullStr | Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes |
title_full_unstemmed | Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes |
title_short | Molecular Processes Involved in the Shared Pathways between Cardiovascular Diseases and Diabetes |
title_sort | molecular processes involved in the shared pathways between cardiovascular diseases and diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604380/ https://www.ncbi.nlm.nih.gov/pubmed/37892985 http://dx.doi.org/10.3390/biomedicines11102611 |
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