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Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel

This work aimed to compare the effect of four new toothpastes (P1–P4) based on pure and biomimetic substituted nano-hydroxyapatites (HAPs) on remineralization of human enamel. Artificially demineralized enamel slices were daily treated for ten days with different toothpastes according to the experim...

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Autores principales: Florea, Alexandra-Diana, Pop, Lucian Cristian, Benea, Horea-Rares-Ciprian, Tomoaia, Gheorghe, Racz, Csaba-Pal, Mocanu, Aurora, Dobrota, Cristina-Teodora, Balint, Reka, Soritau, Olga, Tomoaia-Cotisel, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604461/
https://www.ncbi.nlm.nih.gov/pubmed/37887581
http://dx.doi.org/10.3390/biomimetics8060450
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author Florea, Alexandra-Diana
Pop, Lucian Cristian
Benea, Horea-Rares-Ciprian
Tomoaia, Gheorghe
Racz, Csaba-Pal
Mocanu, Aurora
Dobrota, Cristina-Teodora
Balint, Reka
Soritau, Olga
Tomoaia-Cotisel, Maria
author_facet Florea, Alexandra-Diana
Pop, Lucian Cristian
Benea, Horea-Rares-Ciprian
Tomoaia, Gheorghe
Racz, Csaba-Pal
Mocanu, Aurora
Dobrota, Cristina-Teodora
Balint, Reka
Soritau, Olga
Tomoaia-Cotisel, Maria
author_sort Florea, Alexandra-Diana
collection PubMed
description This work aimed to compare the effect of four new toothpastes (P1–P4) based on pure and biomimetic substituted nano-hydroxyapatites (HAPs) on remineralization of human enamel. Artificially demineralized enamel slices were daily treated for ten days with different toothpastes according to the experimental design. Tooth enamel surfaces were investigated using atomic force microscope (AFM) images and surface roughness (Ra) determined before and after treatment. The surface roughness of enamel slices was statistically analyzed by one-way ANOVA and Bonferroni’s multiple comparison test. X-ray diffraction (XRD) and Fourier transform infrared (FTIR) data revealed the HAP structure with crystal sizes between 28 and 33 nm and crystallinity between 29 and 37%. The average size of HAP particles was found to be between 30 and 40 nm. The Ra values indicated that P3 (HAP-Mg-Zn-Sr-Si) toothpaste was the most effective after 10 days of treatment, leading to the lowest mean roughness. The P3 and P2 (HAP) toothpastes were found to be effective in promoting remineralization. Specifically, their effectiveness can be ranked as follows: P3 = P2 > P4 (HAP-Mg-Zn-Si) > P1 (HAP-Zn), considering both the chemical composition and the size of their constitutive nanoparticles. The proposed toothpastes might be used successfully to treat early tooth decay.
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spelling pubmed-106044612023-10-28 Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel Florea, Alexandra-Diana Pop, Lucian Cristian Benea, Horea-Rares-Ciprian Tomoaia, Gheorghe Racz, Csaba-Pal Mocanu, Aurora Dobrota, Cristina-Teodora Balint, Reka Soritau, Olga Tomoaia-Cotisel, Maria Biomimetics (Basel) Article This work aimed to compare the effect of four new toothpastes (P1–P4) based on pure and biomimetic substituted nano-hydroxyapatites (HAPs) on remineralization of human enamel. Artificially demineralized enamel slices were daily treated for ten days with different toothpastes according to the experimental design. Tooth enamel surfaces were investigated using atomic force microscope (AFM) images and surface roughness (Ra) determined before and after treatment. The surface roughness of enamel slices was statistically analyzed by one-way ANOVA and Bonferroni’s multiple comparison test. X-ray diffraction (XRD) and Fourier transform infrared (FTIR) data revealed the HAP structure with crystal sizes between 28 and 33 nm and crystallinity between 29 and 37%. The average size of HAP particles was found to be between 30 and 40 nm. The Ra values indicated that P3 (HAP-Mg-Zn-Sr-Si) toothpaste was the most effective after 10 days of treatment, leading to the lowest mean roughness. The P3 and P2 (HAP) toothpastes were found to be effective in promoting remineralization. Specifically, their effectiveness can be ranked as follows: P3 = P2 > P4 (HAP-Mg-Zn-Si) > P1 (HAP-Zn), considering both the chemical composition and the size of their constitutive nanoparticles. The proposed toothpastes might be used successfully to treat early tooth decay. MDPI 2023-09-23 /pmc/articles/PMC10604461/ /pubmed/37887581 http://dx.doi.org/10.3390/biomimetics8060450 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Florea, Alexandra-Diana
Pop, Lucian Cristian
Benea, Horea-Rares-Ciprian
Tomoaia, Gheorghe
Racz, Csaba-Pal
Mocanu, Aurora
Dobrota, Cristina-Teodora
Balint, Reka
Soritau, Olga
Tomoaia-Cotisel, Maria
Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel
title Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel
title_full Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel
title_fullStr Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel
title_full_unstemmed Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel
title_short Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel
title_sort remineralization induced by biomimetic hydroxyapatite toothpastes on human enamel
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604461/
https://www.ncbi.nlm.nih.gov/pubmed/37887581
http://dx.doi.org/10.3390/biomimetics8060450
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