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Rapid Segmentation and Diagnosis of Breast Tumor Ultrasound Images at the Sonographer Level Using Deep Learning

Background: Breast cancer is one of the most common malignant tumors in women. A noninvasive ultrasound examination can identify mammary-gland-related diseases and is well tolerated by dense breast, making it a preferred method for breast cancer screening and of significant clinical value. However,...

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Autores principales: Yang, Lei, Zhang, Baichuan, Ren, Fei, Gu, Jianwen, Gao, Jiao, Wu, Jihua, Li, Dan, Jia, Huaping, Li, Guangling, Zong, Jing, Zhang, Jing, Yang, Xiaoman, Zhang, Xueyuan, Du, Baolin, Wang, Xiaowen, Li, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604599/
https://www.ncbi.nlm.nih.gov/pubmed/37892950
http://dx.doi.org/10.3390/bioengineering10101220
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author Yang, Lei
Zhang, Baichuan
Ren, Fei
Gu, Jianwen
Gao, Jiao
Wu, Jihua
Li, Dan
Jia, Huaping
Li, Guangling
Zong, Jing
Zhang, Jing
Yang, Xiaoman
Zhang, Xueyuan
Du, Baolin
Wang, Xiaowen
Li, Na
author_facet Yang, Lei
Zhang, Baichuan
Ren, Fei
Gu, Jianwen
Gao, Jiao
Wu, Jihua
Li, Dan
Jia, Huaping
Li, Guangling
Zong, Jing
Zhang, Jing
Yang, Xiaoman
Zhang, Xueyuan
Du, Baolin
Wang, Xiaowen
Li, Na
author_sort Yang, Lei
collection PubMed
description Background: Breast cancer is one of the most common malignant tumors in women. A noninvasive ultrasound examination can identify mammary-gland-related diseases and is well tolerated by dense breast, making it a preferred method for breast cancer screening and of significant clinical value. However, the diagnosis of breast nodules or masses via ultrasound is performed by a doctor in real time, which is time-consuming and subjective. Junior doctors are prone to missed diagnoses, especially in remote areas or grass-roots hospitals, due to limited medical resources and other factors, which bring great risks to a patient’s health. Therefore, there is an urgent need to develop fast and accurate ultrasound image analysis algorithms to assist diagnoses. Methods: We propose a breast ultrasound image-based assisted-diagnosis method based on convolutional neural networks, which can effectively improve the diagnostic speed and the early screening rate of breast cancer. Our method consists of two stages: tumor recognition and tumor classification. (1) Attention-based semantic segmentation is used to identify the location and size of the tumor; (2) the identified nodules are cropped to construct a training dataset. Then, a convolutional neural network for the diagnosis of benign and malignant breast nodules is trained on this dataset. We collected 2057 images from 1131 patients as the training and validation dataset, and 100 images of the patients with accurate pathological criteria were used as the test dataset. Results: The experimental results based on this dataset show that the MIoU of tumor location recognition is 0.89 and the average accuracy of benign and malignant diagnoses is 97%. The diagnosis performance of the developed diagnostic system is basically consistent with that of senior doctors and is superior to that of junior doctors. In addition, we can provide the doctor with a preliminary diagnosis so that it can be diagnosed quickly. Conclusion: Our proposed method can effectively improve diagnostic speed and the early screening rate of breast cancer. The system provides a valuable aid for the ultrasonic diagnosis of breast cancer.
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spelling pubmed-106045992023-10-28 Rapid Segmentation and Diagnosis of Breast Tumor Ultrasound Images at the Sonographer Level Using Deep Learning Yang, Lei Zhang, Baichuan Ren, Fei Gu, Jianwen Gao, Jiao Wu, Jihua Li, Dan Jia, Huaping Li, Guangling Zong, Jing Zhang, Jing Yang, Xiaoman Zhang, Xueyuan Du, Baolin Wang, Xiaowen Li, Na Bioengineering (Basel) Article Background: Breast cancer is one of the most common malignant tumors in women. A noninvasive ultrasound examination can identify mammary-gland-related diseases and is well tolerated by dense breast, making it a preferred method for breast cancer screening and of significant clinical value. However, the diagnosis of breast nodules or masses via ultrasound is performed by a doctor in real time, which is time-consuming and subjective. Junior doctors are prone to missed diagnoses, especially in remote areas or grass-roots hospitals, due to limited medical resources and other factors, which bring great risks to a patient’s health. Therefore, there is an urgent need to develop fast and accurate ultrasound image analysis algorithms to assist diagnoses. Methods: We propose a breast ultrasound image-based assisted-diagnosis method based on convolutional neural networks, which can effectively improve the diagnostic speed and the early screening rate of breast cancer. Our method consists of two stages: tumor recognition and tumor classification. (1) Attention-based semantic segmentation is used to identify the location and size of the tumor; (2) the identified nodules are cropped to construct a training dataset. Then, a convolutional neural network for the diagnosis of benign and malignant breast nodules is trained on this dataset. We collected 2057 images from 1131 patients as the training and validation dataset, and 100 images of the patients with accurate pathological criteria were used as the test dataset. Results: The experimental results based on this dataset show that the MIoU of tumor location recognition is 0.89 and the average accuracy of benign and malignant diagnoses is 97%. The diagnosis performance of the developed diagnostic system is basically consistent with that of senior doctors and is superior to that of junior doctors. In addition, we can provide the doctor with a preliminary diagnosis so that it can be diagnosed quickly. Conclusion: Our proposed method can effectively improve diagnostic speed and the early screening rate of breast cancer. The system provides a valuable aid for the ultrasonic diagnosis of breast cancer. MDPI 2023-10-19 /pmc/articles/PMC10604599/ /pubmed/37892950 http://dx.doi.org/10.3390/bioengineering10101220 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Lei
Zhang, Baichuan
Ren, Fei
Gu, Jianwen
Gao, Jiao
Wu, Jihua
Li, Dan
Jia, Huaping
Li, Guangling
Zong, Jing
Zhang, Jing
Yang, Xiaoman
Zhang, Xueyuan
Du, Baolin
Wang, Xiaowen
Li, Na
Rapid Segmentation and Diagnosis of Breast Tumor Ultrasound Images at the Sonographer Level Using Deep Learning
title Rapid Segmentation and Diagnosis of Breast Tumor Ultrasound Images at the Sonographer Level Using Deep Learning
title_full Rapid Segmentation and Diagnosis of Breast Tumor Ultrasound Images at the Sonographer Level Using Deep Learning
title_fullStr Rapid Segmentation and Diagnosis of Breast Tumor Ultrasound Images at the Sonographer Level Using Deep Learning
title_full_unstemmed Rapid Segmentation and Diagnosis of Breast Tumor Ultrasound Images at the Sonographer Level Using Deep Learning
title_short Rapid Segmentation and Diagnosis of Breast Tumor Ultrasound Images at the Sonographer Level Using Deep Learning
title_sort rapid segmentation and diagnosis of breast tumor ultrasound images at the sonographer level using deep learning
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604599/
https://www.ncbi.nlm.nih.gov/pubmed/37892950
http://dx.doi.org/10.3390/bioengineering10101220
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