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SF-1 Induces Nuclear PIP2

Metazoan cell nuclei contain non-membrane pools of the phosphoinositide lipid PI(4,5)P2 (PIP2), but how this hydrophobic lipid exists within the aqueous nucleoplasm remains unclear. Steroidogenic Factor-1 (NR5A1, SF-1) is a nuclear receptor that binds PIP2 in vitro, and a co-crystal structure of the...

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Detalles Bibliográficos
Autores principales: Chi, Ethan S., Stivison, Elizabeth A., Blind, Raymond D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604688/
https://www.ncbi.nlm.nih.gov/pubmed/37892191
http://dx.doi.org/10.3390/biom13101509

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