The Role of Biofilms in Contact Lens Associated Fungal Keratitis

Biofilm formation is an important microbial strategy for fungal pathogens, such as Fusarium, Aspergillus, and Candida, to establish keratitis in patients wearing soft contact lenses. Despite the well-documented 2006 outbreak of Fusarium keratitis that eventually led to the withdrawal of the Bausch &...

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Autores principales: Yi, Jipan, Sun, Yao, Zeng, Chenghong, Kostoulias, Xenia, Qu, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604847/
https://www.ncbi.nlm.nih.gov/pubmed/37887234
http://dx.doi.org/10.3390/antibiotics12101533
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author Yi, Jipan
Sun, Yao
Zeng, Chenghong
Kostoulias, Xenia
Qu, Yue
author_facet Yi, Jipan
Sun, Yao
Zeng, Chenghong
Kostoulias, Xenia
Qu, Yue
author_sort Yi, Jipan
collection PubMed
description Biofilm formation is an important microbial strategy for fungal pathogens, such as Fusarium, Aspergillus, and Candida, to establish keratitis in patients wearing soft contact lenses. Despite the well-documented 2006 outbreak of Fusarium keratitis that eventually led to the withdrawal of the Bausch & Lomb multipurpose lens care solution ReNu with MoistureLoc (“MoistureLoc”) from the global market, contact lens care systems and solutions currently available on the market do not specifically target fungal biofilms. This is partially due to the lack of recognition and understanding of important roles that fungal biofilms play in contact lens associated fungal keratitis (CLAFK). This review aims to reemphasize the link between fungal biofilms and CLAFK, and deepen our comprehension of its importance in pathogenesis and persistence of this medical device-related infection.
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spelling pubmed-106048472023-10-28 The Role of Biofilms in Contact Lens Associated Fungal Keratitis Yi, Jipan Sun, Yao Zeng, Chenghong Kostoulias, Xenia Qu, Yue Antibiotics (Basel) Perspective Biofilm formation is an important microbial strategy for fungal pathogens, such as Fusarium, Aspergillus, and Candida, to establish keratitis in patients wearing soft contact lenses. Despite the well-documented 2006 outbreak of Fusarium keratitis that eventually led to the withdrawal of the Bausch & Lomb multipurpose lens care solution ReNu with MoistureLoc (“MoistureLoc”) from the global market, contact lens care systems and solutions currently available on the market do not specifically target fungal biofilms. This is partially due to the lack of recognition and understanding of important roles that fungal biofilms play in contact lens associated fungal keratitis (CLAFK). This review aims to reemphasize the link between fungal biofilms and CLAFK, and deepen our comprehension of its importance in pathogenesis and persistence of this medical device-related infection. MDPI 2023-10-12 /pmc/articles/PMC10604847/ /pubmed/37887234 http://dx.doi.org/10.3390/antibiotics12101533 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Yi, Jipan
Sun, Yao
Zeng, Chenghong
Kostoulias, Xenia
Qu, Yue
The Role of Biofilms in Contact Lens Associated Fungal Keratitis
title The Role of Biofilms in Contact Lens Associated Fungal Keratitis
title_full The Role of Biofilms in Contact Lens Associated Fungal Keratitis
title_fullStr The Role of Biofilms in Contact Lens Associated Fungal Keratitis
title_full_unstemmed The Role of Biofilms in Contact Lens Associated Fungal Keratitis
title_short The Role of Biofilms in Contact Lens Associated Fungal Keratitis
title_sort role of biofilms in contact lens associated fungal keratitis
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604847/
https://www.ncbi.nlm.nih.gov/pubmed/37887234
http://dx.doi.org/10.3390/antibiotics12101533
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