Cargando…
Advancing Nanoscale Science: Synthesis and Bioprinting of Zeolitic Imidazole Framework-8 for Enhanced Anti-Infectious Therapeutic Efficacies
Bacterial infectious disorders are becoming a major health problem for public health. The zeolitic imidazole framework-8 with a novel Cordia myxa extract-based (CME@ZIF-8) nanocomposite showed variable functionality, high porosity, and bacteria-killing activity against Staphylococcus aureus, and Esc...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604899/ https://www.ncbi.nlm.nih.gov/pubmed/37893205 http://dx.doi.org/10.3390/biomedicines11102832 |
_version_ | 1785126945322696704 |
---|---|
author | Saif, Muhammad Saqib Hasan, Murtaza Zafar, Ayesha Ahmed, Muhammad Mahmood Tariq, Tuba Waqas, Muhammad Hussain, Riaz Zafar, Amna Xue, Huang Shu, Xugang |
author_facet | Saif, Muhammad Saqib Hasan, Murtaza Zafar, Ayesha Ahmed, Muhammad Mahmood Tariq, Tuba Waqas, Muhammad Hussain, Riaz Zafar, Amna Xue, Huang Shu, Xugang |
author_sort | Saif, Muhammad Saqib |
collection | PubMed |
description | Bacterial infectious disorders are becoming a major health problem for public health. The zeolitic imidazole framework-8 with a novel Cordia myxa extract-based (CME@ZIF-8) nanocomposite showed variable functionality, high porosity, and bacteria-killing activity against Staphylococcus aureus, and Escherichia coli strains have been created by using a straightforward approach. The sizes of synthesized zeolitic imidazole framework-8 (ZIF-8) and CME@ZIF-8 were 11.38 nm and 12.44 nm, respectively. Prepared metal organic frameworks have been characterized by gas chromatography–mass spectroscopy, Fourier transform spectroscopy, UV–visible spectroscopy, X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. An antibacterial potential comparison between CME@ZIF-8 and zeolitic imidazole framework-8 has shown that CME@ZIF-8 was 31.3%, 28.57%, 46%, and 47% more efficient than ZIF-8 against Staphylococcus aureus and 43.7%, 42.8%, 35.7%, and 70% more efficient against Escherichia coli, while it was 31.25%, 33.3%, 46%, and 46% more efficient than the commercially available ciprofloxacin drug against Staphylococcus aureus and 43.7%, 42.8%, 35.7%, and 70% more efficient against Escherichia coli, respectively, for 750, 500, 250, and 125 μg mL(−1). Minimum inhibitory concentration values of CME@ZIF-8 for Escherichia coli and Staphylococcus aureus were 15.6 and 31.25 μg/mL respectively, while the value of zeolitic imidazole framework-8 alone was 62.5 μg/mL for both Escherichia coli and Staphylococcus aureus. The reactive oxygen species generated by CME@ZIF-8 destroys the bacterial cell and its organelles. Consequently, the CME@ZIF-8 nanocomposites have endless potential applications for treating infectious diseases. |
format | Online Article Text |
id | pubmed-10604899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106048992023-10-28 Advancing Nanoscale Science: Synthesis and Bioprinting of Zeolitic Imidazole Framework-8 for Enhanced Anti-Infectious Therapeutic Efficacies Saif, Muhammad Saqib Hasan, Murtaza Zafar, Ayesha Ahmed, Muhammad Mahmood Tariq, Tuba Waqas, Muhammad Hussain, Riaz Zafar, Amna Xue, Huang Shu, Xugang Biomedicines Article Bacterial infectious disorders are becoming a major health problem for public health. The zeolitic imidazole framework-8 with a novel Cordia myxa extract-based (CME@ZIF-8) nanocomposite showed variable functionality, high porosity, and bacteria-killing activity against Staphylococcus aureus, and Escherichia coli strains have been created by using a straightforward approach. The sizes of synthesized zeolitic imidazole framework-8 (ZIF-8) and CME@ZIF-8 were 11.38 nm and 12.44 nm, respectively. Prepared metal organic frameworks have been characterized by gas chromatography–mass spectroscopy, Fourier transform spectroscopy, UV–visible spectroscopy, X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. An antibacterial potential comparison between CME@ZIF-8 and zeolitic imidazole framework-8 has shown that CME@ZIF-8 was 31.3%, 28.57%, 46%, and 47% more efficient than ZIF-8 against Staphylococcus aureus and 43.7%, 42.8%, 35.7%, and 70% more efficient against Escherichia coli, while it was 31.25%, 33.3%, 46%, and 46% more efficient than the commercially available ciprofloxacin drug against Staphylococcus aureus and 43.7%, 42.8%, 35.7%, and 70% more efficient against Escherichia coli, respectively, for 750, 500, 250, and 125 μg mL(−1). Minimum inhibitory concentration values of CME@ZIF-8 for Escherichia coli and Staphylococcus aureus were 15.6 and 31.25 μg/mL respectively, while the value of zeolitic imidazole framework-8 alone was 62.5 μg/mL for both Escherichia coli and Staphylococcus aureus. The reactive oxygen species generated by CME@ZIF-8 destroys the bacterial cell and its organelles. Consequently, the CME@ZIF-8 nanocomposites have endless potential applications for treating infectious diseases. MDPI 2023-10-18 /pmc/articles/PMC10604899/ /pubmed/37893205 http://dx.doi.org/10.3390/biomedicines11102832 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Saif, Muhammad Saqib Hasan, Murtaza Zafar, Ayesha Ahmed, Muhammad Mahmood Tariq, Tuba Waqas, Muhammad Hussain, Riaz Zafar, Amna Xue, Huang Shu, Xugang Advancing Nanoscale Science: Synthesis and Bioprinting of Zeolitic Imidazole Framework-8 for Enhanced Anti-Infectious Therapeutic Efficacies |
title | Advancing Nanoscale Science: Synthesis and Bioprinting of Zeolitic Imidazole Framework-8 for Enhanced Anti-Infectious Therapeutic Efficacies |
title_full | Advancing Nanoscale Science: Synthesis and Bioprinting of Zeolitic Imidazole Framework-8 for Enhanced Anti-Infectious Therapeutic Efficacies |
title_fullStr | Advancing Nanoscale Science: Synthesis and Bioprinting of Zeolitic Imidazole Framework-8 for Enhanced Anti-Infectious Therapeutic Efficacies |
title_full_unstemmed | Advancing Nanoscale Science: Synthesis and Bioprinting of Zeolitic Imidazole Framework-8 for Enhanced Anti-Infectious Therapeutic Efficacies |
title_short | Advancing Nanoscale Science: Synthesis and Bioprinting of Zeolitic Imidazole Framework-8 for Enhanced Anti-Infectious Therapeutic Efficacies |
title_sort | advancing nanoscale science: synthesis and bioprinting of zeolitic imidazole framework-8 for enhanced anti-infectious therapeutic efficacies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604899/ https://www.ncbi.nlm.nih.gov/pubmed/37893205 http://dx.doi.org/10.3390/biomedicines11102832 |
work_keys_str_mv | AT saifmuhammadsaqib advancingnanoscalesciencesynthesisandbioprintingofzeoliticimidazoleframework8forenhancedantiinfectioustherapeuticefficacies AT hasanmurtaza advancingnanoscalesciencesynthesisandbioprintingofzeoliticimidazoleframework8forenhancedantiinfectioustherapeuticefficacies AT zafarayesha advancingnanoscalesciencesynthesisandbioprintingofzeoliticimidazoleframework8forenhancedantiinfectioustherapeuticefficacies AT ahmedmuhammadmahmood advancingnanoscalesciencesynthesisandbioprintingofzeoliticimidazoleframework8forenhancedantiinfectioustherapeuticefficacies AT tariqtuba advancingnanoscalesciencesynthesisandbioprintingofzeoliticimidazoleframework8forenhancedantiinfectioustherapeuticefficacies AT waqasmuhammad advancingnanoscalesciencesynthesisandbioprintingofzeoliticimidazoleframework8forenhancedantiinfectioustherapeuticefficacies AT hussainriaz advancingnanoscalesciencesynthesisandbioprintingofzeoliticimidazoleframework8forenhancedantiinfectioustherapeuticefficacies AT zafaramna advancingnanoscalesciencesynthesisandbioprintingofzeoliticimidazoleframework8forenhancedantiinfectioustherapeuticefficacies AT xuehuang advancingnanoscalesciencesynthesisandbioprintingofzeoliticimidazoleframework8forenhancedantiinfectioustherapeuticefficacies AT shuxugang advancingnanoscalesciencesynthesisandbioprintingofzeoliticimidazoleframework8forenhancedantiinfectioustherapeuticefficacies |