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Autophagy and Inflammation: Regulatory Roles in Viral Infections

Autophagy is a highly conserved intracellular degradation pathway in eukaryotic organisms, playing an adaptive role in various pathophysiological processes throughout evolution. Inflammation is the immune system’s response to external stimuli and tissue damage. However, persistent inflammatory react...

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Detalles Bibliográficos
Autores principales: Chen, Li, Yang, Limin, Li, Yingyu, Liu, Tianrun, Yang, Bolun, Liu, Lei, Wu, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604974/
https://www.ncbi.nlm.nih.gov/pubmed/37892135
http://dx.doi.org/10.3390/biom13101454
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author Chen, Li
Yang, Limin
Li, Yingyu
Liu, Tianrun
Yang, Bolun
Liu, Lei
Wu, Rui
author_facet Chen, Li
Yang, Limin
Li, Yingyu
Liu, Tianrun
Yang, Bolun
Liu, Lei
Wu, Rui
author_sort Chen, Li
collection PubMed
description Autophagy is a highly conserved intracellular degradation pathway in eukaryotic organisms, playing an adaptive role in various pathophysiological processes throughout evolution. Inflammation is the immune system’s response to external stimuli and tissue damage. However, persistent inflammatory reactions can lead to a range of inflammatory diseases and cancers. The interaction between autophagy and inflammation is particularly evident during viral infections. As a crucial regulator of inflammation, autophagy can either promote or inhibit the occurrence of inflammatory responses. In turn, inflammation can establish negative feedback loops by modulating autophagy to suppress excessive inflammatory reactions. This interaction is pivotal in the pathogenesis of viral diseases. Therefore, elucidating the regulatory roles of autophagy and inflammation in viral infections will significantly enhance our understanding of the mechanisms underlying related diseases. Furthermore, it will provide new insights and theoretical foundations for disease prevention, treatment, and drug development.
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spelling pubmed-106049742023-10-28 Autophagy and Inflammation: Regulatory Roles in Viral Infections Chen, Li Yang, Limin Li, Yingyu Liu, Tianrun Yang, Bolun Liu, Lei Wu, Rui Biomolecules Review Autophagy is a highly conserved intracellular degradation pathway in eukaryotic organisms, playing an adaptive role in various pathophysiological processes throughout evolution. Inflammation is the immune system’s response to external stimuli and tissue damage. However, persistent inflammatory reactions can lead to a range of inflammatory diseases and cancers. The interaction between autophagy and inflammation is particularly evident during viral infections. As a crucial regulator of inflammation, autophagy can either promote or inhibit the occurrence of inflammatory responses. In turn, inflammation can establish negative feedback loops by modulating autophagy to suppress excessive inflammatory reactions. This interaction is pivotal in the pathogenesis of viral diseases. Therefore, elucidating the regulatory roles of autophagy and inflammation in viral infections will significantly enhance our understanding of the mechanisms underlying related diseases. Furthermore, it will provide new insights and theoretical foundations for disease prevention, treatment, and drug development. MDPI 2023-09-27 /pmc/articles/PMC10604974/ /pubmed/37892135 http://dx.doi.org/10.3390/biom13101454 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Li
Yang, Limin
Li, Yingyu
Liu, Tianrun
Yang, Bolun
Liu, Lei
Wu, Rui
Autophagy and Inflammation: Regulatory Roles in Viral Infections
title Autophagy and Inflammation: Regulatory Roles in Viral Infections
title_full Autophagy and Inflammation: Regulatory Roles in Viral Infections
title_fullStr Autophagy and Inflammation: Regulatory Roles in Viral Infections
title_full_unstemmed Autophagy and Inflammation: Regulatory Roles in Viral Infections
title_short Autophagy and Inflammation: Regulatory Roles in Viral Infections
title_sort autophagy and inflammation: regulatory roles in viral infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604974/
https://www.ncbi.nlm.nih.gov/pubmed/37892135
http://dx.doi.org/10.3390/biom13101454
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