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Transcranial Direct Current Stimulation of Primary Motor Cortex over Multiple Days Improves Motor Learning of a Complex Overhand Throwing Task

Transcranial direct current stimulation (tDCS) applied to the primary motor cortex (M1) improves motor learning in relatively simple motor tasks performed with the hand and arm. However, it is unknown if tDCS can improve motor learning in complex motor tasks involving whole-body coordination with si...

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Autores principales: Pantovic, Milan, de Albuquerque, Lidio Lima, Mastrantonio, Sierra, Pomerantz, Austin S., Wilkins, Erik W., Riley, Zachary A., Guadagnoli, Mark A., Poston, Brach
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604977/
https://www.ncbi.nlm.nih.gov/pubmed/37891809
http://dx.doi.org/10.3390/brainsci13101441
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author Pantovic, Milan
de Albuquerque, Lidio Lima
Mastrantonio, Sierra
Pomerantz, Austin S.
Wilkins, Erik W.
Riley, Zachary A.
Guadagnoli, Mark A.
Poston, Brach
author_facet Pantovic, Milan
de Albuquerque, Lidio Lima
Mastrantonio, Sierra
Pomerantz, Austin S.
Wilkins, Erik W.
Riley, Zachary A.
Guadagnoli, Mark A.
Poston, Brach
author_sort Pantovic, Milan
collection PubMed
description Transcranial direct current stimulation (tDCS) applied to the primary motor cortex (M1) improves motor learning in relatively simple motor tasks performed with the hand and arm. However, it is unknown if tDCS can improve motor learning in complex motor tasks involving whole-body coordination with significant endpoint accuracy requirements. The primary purpose was to determine the influence of tDCS on motor learning over multiple days in a complex over-hand throwing task. This study utilized a double-blind, randomized, SHAM-controlled, between-subjects experimental design. Forty-six young adults were allocated to either a tDCS group or a SHAM group and completed three experimental sessions on three consecutive days at the same time of day. Each experimental session was identical and consisted of overhand throwing trials to a target in a pre-test block, five practice blocks performed simultaneously with 20 min of tDCS, and a post-test block. Overhand throwing performance was quantified as the endpoint error. Transcranial magnetic stimulation was used to obtain motor-evoked potentials (MEPs) from the first dorsal interosseus muscle to quantify changes in M1 excitability due to tDCS. Endpoint error significantly decreased over the three days of practice in the tDCS group but not in the SHAM group. MEP amplitude significantly increased in the tDCS group, but the MEP increases were not associated with increases in motor learning. These findings indicate that tDCS applied over multiple days can improve motor learning in a complex motor tasks in healthy young adults.
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spelling pubmed-106049772023-10-28 Transcranial Direct Current Stimulation of Primary Motor Cortex over Multiple Days Improves Motor Learning of a Complex Overhand Throwing Task Pantovic, Milan de Albuquerque, Lidio Lima Mastrantonio, Sierra Pomerantz, Austin S. Wilkins, Erik W. Riley, Zachary A. Guadagnoli, Mark A. Poston, Brach Brain Sci Article Transcranial direct current stimulation (tDCS) applied to the primary motor cortex (M1) improves motor learning in relatively simple motor tasks performed with the hand and arm. However, it is unknown if tDCS can improve motor learning in complex motor tasks involving whole-body coordination with significant endpoint accuracy requirements. The primary purpose was to determine the influence of tDCS on motor learning over multiple days in a complex over-hand throwing task. This study utilized a double-blind, randomized, SHAM-controlled, between-subjects experimental design. Forty-six young adults were allocated to either a tDCS group or a SHAM group and completed three experimental sessions on three consecutive days at the same time of day. Each experimental session was identical and consisted of overhand throwing trials to a target in a pre-test block, five practice blocks performed simultaneously with 20 min of tDCS, and a post-test block. Overhand throwing performance was quantified as the endpoint error. Transcranial magnetic stimulation was used to obtain motor-evoked potentials (MEPs) from the first dorsal interosseus muscle to quantify changes in M1 excitability due to tDCS. Endpoint error significantly decreased over the three days of practice in the tDCS group but not in the SHAM group. MEP amplitude significantly increased in the tDCS group, but the MEP increases were not associated with increases in motor learning. These findings indicate that tDCS applied over multiple days can improve motor learning in a complex motor tasks in healthy young adults. MDPI 2023-10-10 /pmc/articles/PMC10604977/ /pubmed/37891809 http://dx.doi.org/10.3390/brainsci13101441 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pantovic, Milan
de Albuquerque, Lidio Lima
Mastrantonio, Sierra
Pomerantz, Austin S.
Wilkins, Erik W.
Riley, Zachary A.
Guadagnoli, Mark A.
Poston, Brach
Transcranial Direct Current Stimulation of Primary Motor Cortex over Multiple Days Improves Motor Learning of a Complex Overhand Throwing Task
title Transcranial Direct Current Stimulation of Primary Motor Cortex over Multiple Days Improves Motor Learning of a Complex Overhand Throwing Task
title_full Transcranial Direct Current Stimulation of Primary Motor Cortex over Multiple Days Improves Motor Learning of a Complex Overhand Throwing Task
title_fullStr Transcranial Direct Current Stimulation of Primary Motor Cortex over Multiple Days Improves Motor Learning of a Complex Overhand Throwing Task
title_full_unstemmed Transcranial Direct Current Stimulation of Primary Motor Cortex over Multiple Days Improves Motor Learning of a Complex Overhand Throwing Task
title_short Transcranial Direct Current Stimulation of Primary Motor Cortex over Multiple Days Improves Motor Learning of a Complex Overhand Throwing Task
title_sort transcranial direct current stimulation of primary motor cortex over multiple days improves motor learning of a complex overhand throwing task
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604977/
https://www.ncbi.nlm.nih.gov/pubmed/37891809
http://dx.doi.org/10.3390/brainsci13101441
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