Local Control Following Stereotactic Body Radiation Therapy for Liver Oligometastases: Lessons from a Quarter Century

The utilization of stereotactic body radiation therapy for the treatment of liver metastasis has been widely studied and has demonstrated favorable local control outcomes. However, several predictive factors play a crucial role in the efficacy of stereotactic body radiation therapy, such as the numb...

Descripción completa

Detalles Bibliográficos
Autores principales: Mheid, Sara, Allen, Stefan, Ng, Sylvia S. W., Hall, William A., Sanford, Nina N., Aguilera, Todd A., Elamir, Ahmed M., Bahij, Rana, Intven, Martijn P. W., Radhakrishna, Ganesh, Mohamad, Issa, De Leon, Jeremy, Tan, Hendrick, Lewis, Shirley, Gani, Cihan, Stanecu, Teo, Dell’Acqua, Veronica, Hosni, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605011/
https://www.ncbi.nlm.nih.gov/pubmed/37887567
http://dx.doi.org/10.3390/curroncol30100667
Descripción
Sumario:The utilization of stereotactic body radiation therapy for the treatment of liver metastasis has been widely studied and has demonstrated favorable local control outcomes. However, several predictive factors play a crucial role in the efficacy of stereotactic body radiation therapy, such as the number and size (volume) of metastatic liver lesions, the primary tumor site (histology), molecular biomarkers (e.g., KRAS and TP53 mutation), the use of systemic therapy prior to SBRT, the radiation dose, and the use of advanced technology and organ motion management during SBRT. These prognostic factors need to be considered when clinical trials are designed to evaluate the efficacy of SBRT for liver metastases.

Ejemplares similares