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Gut–Brain Crosstalk and the Central Mechanisms of Orofacial Pain

Accumulated evidence has demonstrated that the gut microbiome can contribute to pain modulation through the microbiome–gut–brain axis. Various relevant microbiome metabolites in the gut are involved in the regulation of pain signaling in the central nervous system. In this review, we summarize recen...

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Autores principales: Tao, Ran, Liu, Sufang, Crawford, Joshua, Tao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605055/
https://www.ncbi.nlm.nih.gov/pubmed/37891825
http://dx.doi.org/10.3390/brainsci13101456
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author Tao, Ran
Liu, Sufang
Crawford, Joshua
Tao, Feng
author_facet Tao, Ran
Liu, Sufang
Crawford, Joshua
Tao, Feng
author_sort Tao, Ran
collection PubMed
description Accumulated evidence has demonstrated that the gut microbiome can contribute to pain modulation through the microbiome–gut–brain axis. Various relevant microbiome metabolites in the gut are involved in the regulation of pain signaling in the central nervous system. In this review, we summarize recent advances in gut–brain interactions by which the microbiome metabolites modulate pain, with a focus on orofacial pain, and we further discuss the role of gut–brain crosstalk in the central mechanisms of orofacial pain whereby the gut microbiome modulates orofacial pain via the vagus nerve-mediated direct pathway and the gut metabolites/molecules-mediated indirect pathway. The direct and indirect pathways both contribute to the central regulation of orofacial pain through different brain structures (such as the nucleus tractus solitarius and the parabrachial nucleus) and signaling transmission across the blood-brain barrier, respectively. Understanding the gut microbiome-regulated pain mechanisms in the brain could help us to develop non-opioid novel therapies for orofacial pain.
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spelling pubmed-106050552023-10-28 Gut–Brain Crosstalk and the Central Mechanisms of Orofacial Pain Tao, Ran Liu, Sufang Crawford, Joshua Tao, Feng Brain Sci Review Accumulated evidence has demonstrated that the gut microbiome can contribute to pain modulation through the microbiome–gut–brain axis. Various relevant microbiome metabolites in the gut are involved in the regulation of pain signaling in the central nervous system. In this review, we summarize recent advances in gut–brain interactions by which the microbiome metabolites modulate pain, with a focus on orofacial pain, and we further discuss the role of gut–brain crosstalk in the central mechanisms of orofacial pain whereby the gut microbiome modulates orofacial pain via the vagus nerve-mediated direct pathway and the gut metabolites/molecules-mediated indirect pathway. The direct and indirect pathways both contribute to the central regulation of orofacial pain through different brain structures (such as the nucleus tractus solitarius and the parabrachial nucleus) and signaling transmission across the blood-brain barrier, respectively. Understanding the gut microbiome-regulated pain mechanisms in the brain could help us to develop non-opioid novel therapies for orofacial pain. MDPI 2023-10-13 /pmc/articles/PMC10605055/ /pubmed/37891825 http://dx.doi.org/10.3390/brainsci13101456 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tao, Ran
Liu, Sufang
Crawford, Joshua
Tao, Feng
Gut–Brain Crosstalk and the Central Mechanisms of Orofacial Pain
title Gut–Brain Crosstalk and the Central Mechanisms of Orofacial Pain
title_full Gut–Brain Crosstalk and the Central Mechanisms of Orofacial Pain
title_fullStr Gut–Brain Crosstalk and the Central Mechanisms of Orofacial Pain
title_full_unstemmed Gut–Brain Crosstalk and the Central Mechanisms of Orofacial Pain
title_short Gut–Brain Crosstalk and the Central Mechanisms of Orofacial Pain
title_sort gut–brain crosstalk and the central mechanisms of orofacial pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605055/
https://www.ncbi.nlm.nih.gov/pubmed/37891825
http://dx.doi.org/10.3390/brainsci13101456
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