TIM-3 Expression and M2 Polarization of Macrophages in the TGFβ-Activated Tumor Microenvironment in Colorectal Cancer

SIMPLE SUMMARY: TGFβ and TIM-3 have been implicated in driving immune evasion and poor response to anti-PD-1/PD-L1 immune checkpoint inhibitors (ICIs). Using large-scale transcriptomic data analysis, followed by immunohistochemistry and in vitro experiments, we demonstrated a strong link between TIM...

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Detalles Bibliográficos
Autores principales: Katagata, Masanori, Okayama, Hirokazu, Nakajima, Shotaro, Saito, Katsuharu, Sato, Takahiro, Sakuma, Mei, Fukai, Satoshi, Endo, Eisei, Sakamoto, Wataru, Saito, Motonobu, Saze, Zenichiro, Momma, Tomoyuki, Mimura, Kosaku, Kono, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605063/
https://www.ncbi.nlm.nih.gov/pubmed/37894310
http://dx.doi.org/10.3390/cancers15204943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605063/
https://www.ncbi.nlm.nih.gov/pubmed/37894310
http://dx.doi.org/10.3390/cancers15204943

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