Structural elucidation of a compound extracted from Streptomyces Sp.NLKB45

A Streptomyces Sp. NLKB45 was isolated from the Nellore coastal region. After checking antimicrobial and antifungal activity the strain was subjected to fermentation in starch casein broth medium. HPLC was used to purify the culture filtrate after it had been extracted with ethyl acetate. The extrac...

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Autores principales: Sudha Kalyani, B, Amrutharaj, B, Krishna, PS, Sreenivasulu, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605086/
https://www.ncbi.nlm.nih.gov/pubmed/37901294
http://dx.doi.org/10.6026/97320630019820
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author Sudha Kalyani, B
Amrutharaj, B
Krishna, PS
Sreenivasulu, K
author_facet Sudha Kalyani, B
Amrutharaj, B
Krishna, PS
Sreenivasulu, K
author_sort Sudha Kalyani, B
collection PubMed
description A Streptomyces Sp. NLKB45 was isolated from the Nellore coastal region. After checking antimicrobial and antifungal activity the strain was subjected to fermentation in starch casein broth medium. HPLC was used to purify the culture filtrate after it had been extracted with ethyl acetate. The extract showed antibacterial and anticancer properties. The extract was processed and the compound isolated was further analyzed using FTIR, mass spectroscopic method and one- and two-dimensional NMR techniques. Based on the data gathered the compound was identified as 7-((5-methylpyridin-2-ylamino) (phenyl) methyl) quinolin-8-ol with a weight-average molecular weight of about 341 Da.
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spelling pubmed-106050862023-10-28 Structural elucidation of a compound extracted from Streptomyces Sp.NLKB45 Sudha Kalyani, B Amrutharaj, B Krishna, PS Sreenivasulu, K Bioinformation Research Article A Streptomyces Sp. NLKB45 was isolated from the Nellore coastal region. After checking antimicrobial and antifungal activity the strain was subjected to fermentation in starch casein broth medium. HPLC was used to purify the culture filtrate after it had been extracted with ethyl acetate. The extract showed antibacterial and anticancer properties. The extract was processed and the compound isolated was further analyzed using FTIR, mass spectroscopic method and one- and two-dimensional NMR techniques. Based on the data gathered the compound was identified as 7-((5-methylpyridin-2-ylamino) (phenyl) methyl) quinolin-8-ol with a weight-average molecular weight of about 341 Da. Biomedical Informatics 2023-07-31 /pmc/articles/PMC10605086/ /pubmed/37901294 http://dx.doi.org/10.6026/97320630019820 Text en © 2023 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Sudha Kalyani, B
Amrutharaj, B
Krishna, PS
Sreenivasulu, K
Structural elucidation of a compound extracted from Streptomyces Sp.NLKB45
title Structural elucidation of a compound extracted from Streptomyces Sp.NLKB45
title_full Structural elucidation of a compound extracted from Streptomyces Sp.NLKB45
title_fullStr Structural elucidation of a compound extracted from Streptomyces Sp.NLKB45
title_full_unstemmed Structural elucidation of a compound extracted from Streptomyces Sp.NLKB45
title_short Structural elucidation of a compound extracted from Streptomyces Sp.NLKB45
title_sort structural elucidation of a compound extracted from streptomyces sp.nlkb45
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605086/
https://www.ncbi.nlm.nih.gov/pubmed/37901294
http://dx.doi.org/10.6026/97320630019820
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