Cargando…

Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review

Combined antiretroviral therapy (cART) has greatly reduced the severity of HIV-associated neurocognitive disorders in people living with HIV (PLWH); however, PLWH are more likely than the general population to use drugs and suffer from substance use disorders (SUDs) and to exhibit risky behaviors th...

Descripción completa

Detalles Bibliográficos
Autores principales: Vines, Leah, Sotelo, Diana, Giddens, Natasha, Manza, Peter, Volkow, Nora D., Wang, Gene-Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605099/
https://www.ncbi.nlm.nih.gov/pubmed/37891847
http://dx.doi.org/10.3390/brainsci13101480
_version_ 1785126992356573184
author Vines, Leah
Sotelo, Diana
Giddens, Natasha
Manza, Peter
Volkow, Nora D.
Wang, Gene-Jack
author_facet Vines, Leah
Sotelo, Diana
Giddens, Natasha
Manza, Peter
Volkow, Nora D.
Wang, Gene-Jack
author_sort Vines, Leah
collection PubMed
description Combined antiretroviral therapy (cART) has greatly reduced the severity of HIV-associated neurocognitive disorders in people living with HIV (PLWH); however, PLWH are more likely than the general population to use drugs and suffer from substance use disorders (SUDs) and to exhibit risky behaviors that promote HIV transmission and other infections. Dopamine-boosting psychostimulants such as cocaine and methamphetamine are some of the most widely used substances among PLWH. Chronic use of these substances disrupts brain function, structure, and cognition. PLWH with SUD have poor health outcomes driven by complex interactions between biological, neurocognitive, and social factors. Here we review the effects of comorbid HIV and psychostimulant use disorders by discussing the distinct and common effects of HIV and chronic cocaine and methamphetamine use on behavioral and neurological impairments using evidence from rodent models of HIV-associated neurocognitive impairments (Tat or gp120 protein expression) and clinical studies. We also provide a biopsychosocial perspective by discussing behavioral impairment in differentially impacted social groups and proposing interventions at both patient and population levels.
format Online
Article
Text
id pubmed-10605099
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106050992023-10-28 Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review Vines, Leah Sotelo, Diana Giddens, Natasha Manza, Peter Volkow, Nora D. Wang, Gene-Jack Brain Sci Review Combined antiretroviral therapy (cART) has greatly reduced the severity of HIV-associated neurocognitive disorders in people living with HIV (PLWH); however, PLWH are more likely than the general population to use drugs and suffer from substance use disorders (SUDs) and to exhibit risky behaviors that promote HIV transmission and other infections. Dopamine-boosting psychostimulants such as cocaine and methamphetamine are some of the most widely used substances among PLWH. Chronic use of these substances disrupts brain function, structure, and cognition. PLWH with SUD have poor health outcomes driven by complex interactions between biological, neurocognitive, and social factors. Here we review the effects of comorbid HIV and psychostimulant use disorders by discussing the distinct and common effects of HIV and chronic cocaine and methamphetamine use on behavioral and neurological impairments using evidence from rodent models of HIV-associated neurocognitive impairments (Tat or gp120 protein expression) and clinical studies. We also provide a biopsychosocial perspective by discussing behavioral impairment in differentially impacted social groups and proposing interventions at both patient and population levels. MDPI 2023-10-19 /pmc/articles/PMC10605099/ /pubmed/37891847 http://dx.doi.org/10.3390/brainsci13101480 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vines, Leah
Sotelo, Diana
Giddens, Natasha
Manza, Peter
Volkow, Nora D.
Wang, Gene-Jack
Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review
title Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review
title_full Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review
title_fullStr Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review
title_full_unstemmed Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review
title_short Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review
title_sort neurological, behavioral, and pathophysiological characterization of the co-occurrence of substance use and hiv: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605099/
https://www.ncbi.nlm.nih.gov/pubmed/37891847
http://dx.doi.org/10.3390/brainsci13101480
work_keys_str_mv AT vinesleah neurologicalbehavioralandpathophysiologicalcharacterizationofthecooccurrenceofsubstanceuseandhivanarrativereview
AT sotelodiana neurologicalbehavioralandpathophysiologicalcharacterizationofthecooccurrenceofsubstanceuseandhivanarrativereview
AT giddensnatasha neurologicalbehavioralandpathophysiologicalcharacterizationofthecooccurrenceofsubstanceuseandhivanarrativereview
AT manzapeter neurologicalbehavioralandpathophysiologicalcharacterizationofthecooccurrenceofsubstanceuseandhivanarrativereview
AT volkownorad neurologicalbehavioralandpathophysiologicalcharacterizationofthecooccurrenceofsubstanceuseandhivanarrativereview
AT wanggenejack neurologicalbehavioralandpathophysiologicalcharacterizationofthecooccurrenceofsubstanceuseandhivanarrativereview