Cargando…
Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review
Combined antiretroviral therapy (cART) has greatly reduced the severity of HIV-associated neurocognitive disorders in people living with HIV (PLWH); however, PLWH are more likely than the general population to use drugs and suffer from substance use disorders (SUDs) and to exhibit risky behaviors th...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605099/ https://www.ncbi.nlm.nih.gov/pubmed/37891847 http://dx.doi.org/10.3390/brainsci13101480 |
_version_ | 1785126992356573184 |
---|---|
author | Vines, Leah Sotelo, Diana Giddens, Natasha Manza, Peter Volkow, Nora D. Wang, Gene-Jack |
author_facet | Vines, Leah Sotelo, Diana Giddens, Natasha Manza, Peter Volkow, Nora D. Wang, Gene-Jack |
author_sort | Vines, Leah |
collection | PubMed |
description | Combined antiretroviral therapy (cART) has greatly reduced the severity of HIV-associated neurocognitive disorders in people living with HIV (PLWH); however, PLWH are more likely than the general population to use drugs and suffer from substance use disorders (SUDs) and to exhibit risky behaviors that promote HIV transmission and other infections. Dopamine-boosting psychostimulants such as cocaine and methamphetamine are some of the most widely used substances among PLWH. Chronic use of these substances disrupts brain function, structure, and cognition. PLWH with SUD have poor health outcomes driven by complex interactions between biological, neurocognitive, and social factors. Here we review the effects of comorbid HIV and psychostimulant use disorders by discussing the distinct and common effects of HIV and chronic cocaine and methamphetamine use on behavioral and neurological impairments using evidence from rodent models of HIV-associated neurocognitive impairments (Tat or gp120 protein expression) and clinical studies. We also provide a biopsychosocial perspective by discussing behavioral impairment in differentially impacted social groups and proposing interventions at both patient and population levels. |
format | Online Article Text |
id | pubmed-10605099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106050992023-10-28 Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review Vines, Leah Sotelo, Diana Giddens, Natasha Manza, Peter Volkow, Nora D. Wang, Gene-Jack Brain Sci Review Combined antiretroviral therapy (cART) has greatly reduced the severity of HIV-associated neurocognitive disorders in people living with HIV (PLWH); however, PLWH are more likely than the general population to use drugs and suffer from substance use disorders (SUDs) and to exhibit risky behaviors that promote HIV transmission and other infections. Dopamine-boosting psychostimulants such as cocaine and methamphetamine are some of the most widely used substances among PLWH. Chronic use of these substances disrupts brain function, structure, and cognition. PLWH with SUD have poor health outcomes driven by complex interactions between biological, neurocognitive, and social factors. Here we review the effects of comorbid HIV and psychostimulant use disorders by discussing the distinct and common effects of HIV and chronic cocaine and methamphetamine use on behavioral and neurological impairments using evidence from rodent models of HIV-associated neurocognitive impairments (Tat or gp120 protein expression) and clinical studies. We also provide a biopsychosocial perspective by discussing behavioral impairment in differentially impacted social groups and proposing interventions at both patient and population levels. MDPI 2023-10-19 /pmc/articles/PMC10605099/ /pubmed/37891847 http://dx.doi.org/10.3390/brainsci13101480 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Vines, Leah Sotelo, Diana Giddens, Natasha Manza, Peter Volkow, Nora D. Wang, Gene-Jack Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review |
title | Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review |
title_full | Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review |
title_fullStr | Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review |
title_full_unstemmed | Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review |
title_short | Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review |
title_sort | neurological, behavioral, and pathophysiological characterization of the co-occurrence of substance use and hiv: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605099/ https://www.ncbi.nlm.nih.gov/pubmed/37891847 http://dx.doi.org/10.3390/brainsci13101480 |
work_keys_str_mv | AT vinesleah neurologicalbehavioralandpathophysiologicalcharacterizationofthecooccurrenceofsubstanceuseandhivanarrativereview AT sotelodiana neurologicalbehavioralandpathophysiologicalcharacterizationofthecooccurrenceofsubstanceuseandhivanarrativereview AT giddensnatasha neurologicalbehavioralandpathophysiologicalcharacterizationofthecooccurrenceofsubstanceuseandhivanarrativereview AT manzapeter neurologicalbehavioralandpathophysiologicalcharacterizationofthecooccurrenceofsubstanceuseandhivanarrativereview AT volkownorad neurologicalbehavioralandpathophysiologicalcharacterizationofthecooccurrenceofsubstanceuseandhivanarrativereview AT wanggenejack neurologicalbehavioralandpathophysiologicalcharacterizationofthecooccurrenceofsubstanceuseandhivanarrativereview |