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Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons

Cerebral injury is a leading cause of long-term disability and mortality. Common causes include major cardiovascular events, such as cardiac arrest, ischemic stroke, and subarachnoid hemorrhage, traumatic brain injury, and neurodegenerative as well as neuroinflammatory disorders. Despite improvement...

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Detalles Bibliográficos
Autores principales: Scheid, Stefanie, Goebel, Ulrich, Ulbrich, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605176/
https://www.ncbi.nlm.nih.gov/pubmed/37887324
http://dx.doi.org/10.3390/cells12202480
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author Scheid, Stefanie
Goebel, Ulrich
Ulbrich, Felix
author_facet Scheid, Stefanie
Goebel, Ulrich
Ulbrich, Felix
author_sort Scheid, Stefanie
collection PubMed
description Cerebral injury is a leading cause of long-term disability and mortality. Common causes include major cardiovascular events, such as cardiac arrest, ischemic stroke, and subarachnoid hemorrhage, traumatic brain injury, and neurodegenerative as well as neuroinflammatory disorders. Despite improvements in pharmacological and interventional treatment options, due to the brain’s limited regeneration potential, survival is often associated with the impairment of crucial functions that lead to occupational inability and enormous economic burden. For decades, researchers have therefore been investigating adjuvant therapeutic options to alleviate neuronal cell death. Although promising in preclinical studies, a huge variety of drugs thought to provide neuroprotective effects failed in clinical trials. However, utilizing medical gases, noble gases, and gaseous molecules as supportive treatment options may offer new perspectives for patients suffering neuronal damage. This review provides an overview of current research, potentials and mechanisms of these substances as a promising therapeutic alternative for the treatment of cerebral injury.
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spelling pubmed-106051762023-10-28 Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons Scheid, Stefanie Goebel, Ulrich Ulbrich, Felix Cells Review Cerebral injury is a leading cause of long-term disability and mortality. Common causes include major cardiovascular events, such as cardiac arrest, ischemic stroke, and subarachnoid hemorrhage, traumatic brain injury, and neurodegenerative as well as neuroinflammatory disorders. Despite improvements in pharmacological and interventional treatment options, due to the brain’s limited regeneration potential, survival is often associated with the impairment of crucial functions that lead to occupational inability and enormous economic burden. For decades, researchers have therefore been investigating adjuvant therapeutic options to alleviate neuronal cell death. Although promising in preclinical studies, a huge variety of drugs thought to provide neuroprotective effects failed in clinical trials. However, utilizing medical gases, noble gases, and gaseous molecules as supportive treatment options may offer new perspectives for patients suffering neuronal damage. This review provides an overview of current research, potentials and mechanisms of these substances as a promising therapeutic alternative for the treatment of cerebral injury. MDPI 2023-10-18 /pmc/articles/PMC10605176/ /pubmed/37887324 http://dx.doi.org/10.3390/cells12202480 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Scheid, Stefanie
Goebel, Ulrich
Ulbrich, Felix
Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons
title Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons
title_full Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons
title_fullStr Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons
title_full_unstemmed Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons
title_short Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons
title_sort neuroprotection is in the air—inhaled gases on their way to the neurons
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605176/
https://www.ncbi.nlm.nih.gov/pubmed/37887324
http://dx.doi.org/10.3390/cells12202480
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