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Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons
Cerebral injury is a leading cause of long-term disability and mortality. Common causes include major cardiovascular events, such as cardiac arrest, ischemic stroke, and subarachnoid hemorrhage, traumatic brain injury, and neurodegenerative as well as neuroinflammatory disorders. Despite improvement...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605176/ https://www.ncbi.nlm.nih.gov/pubmed/37887324 http://dx.doi.org/10.3390/cells12202480 |
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author | Scheid, Stefanie Goebel, Ulrich Ulbrich, Felix |
author_facet | Scheid, Stefanie Goebel, Ulrich Ulbrich, Felix |
author_sort | Scheid, Stefanie |
collection | PubMed |
description | Cerebral injury is a leading cause of long-term disability and mortality. Common causes include major cardiovascular events, such as cardiac arrest, ischemic stroke, and subarachnoid hemorrhage, traumatic brain injury, and neurodegenerative as well as neuroinflammatory disorders. Despite improvements in pharmacological and interventional treatment options, due to the brain’s limited regeneration potential, survival is often associated with the impairment of crucial functions that lead to occupational inability and enormous economic burden. For decades, researchers have therefore been investigating adjuvant therapeutic options to alleviate neuronal cell death. Although promising in preclinical studies, a huge variety of drugs thought to provide neuroprotective effects failed in clinical trials. However, utilizing medical gases, noble gases, and gaseous molecules as supportive treatment options may offer new perspectives for patients suffering neuronal damage. This review provides an overview of current research, potentials and mechanisms of these substances as a promising therapeutic alternative for the treatment of cerebral injury. |
format | Online Article Text |
id | pubmed-10605176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106051762023-10-28 Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons Scheid, Stefanie Goebel, Ulrich Ulbrich, Felix Cells Review Cerebral injury is a leading cause of long-term disability and mortality. Common causes include major cardiovascular events, such as cardiac arrest, ischemic stroke, and subarachnoid hemorrhage, traumatic brain injury, and neurodegenerative as well as neuroinflammatory disorders. Despite improvements in pharmacological and interventional treatment options, due to the brain’s limited regeneration potential, survival is often associated with the impairment of crucial functions that lead to occupational inability and enormous economic burden. For decades, researchers have therefore been investigating adjuvant therapeutic options to alleviate neuronal cell death. Although promising in preclinical studies, a huge variety of drugs thought to provide neuroprotective effects failed in clinical trials. However, utilizing medical gases, noble gases, and gaseous molecules as supportive treatment options may offer new perspectives for patients suffering neuronal damage. This review provides an overview of current research, potentials and mechanisms of these substances as a promising therapeutic alternative for the treatment of cerebral injury. MDPI 2023-10-18 /pmc/articles/PMC10605176/ /pubmed/37887324 http://dx.doi.org/10.3390/cells12202480 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Scheid, Stefanie Goebel, Ulrich Ulbrich, Felix Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons |
title | Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons |
title_full | Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons |
title_fullStr | Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons |
title_full_unstemmed | Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons |
title_short | Neuroprotection Is in the Air—Inhaled Gases on Their Way to the Neurons |
title_sort | neuroprotection is in the air—inhaled gases on their way to the neurons |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605176/ https://www.ncbi.nlm.nih.gov/pubmed/37887324 http://dx.doi.org/10.3390/cells12202480 |
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