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Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine

Nasal nitric oxide (nNO) is a gas synthesized by the inducible and constitutive NO synthase (NOS) enzyme in the airway cells of the nasal mucosa. Like lung nitric oxide, it is thought to be associated with airway inflammation in various respiratory diseases in children. The aim of our review was to...

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Autores principales: Mrkić Kobal, Iva, Turkalj, Mirjana, Plavec, Davor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605182/
https://www.ncbi.nlm.nih.gov/pubmed/37892334
http://dx.doi.org/10.3390/children10101671
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author Mrkić Kobal, Iva
Turkalj, Mirjana
Plavec, Davor
author_facet Mrkić Kobal, Iva
Turkalj, Mirjana
Plavec, Davor
author_sort Mrkić Kobal, Iva
collection PubMed
description Nasal nitric oxide (nNO) is a gas synthesized by the inducible and constitutive NO synthase (NOS) enzyme in the airway cells of the nasal mucosa. Like lung nitric oxide, it is thought to be associated with airway inflammation in various respiratory diseases in children. The aim of our review was to investigate the current state of use of nNO measurement in children. A comprehensive search was conducted using the Web of Science and PubMed databases specifically targeting publications in the English language, with the following keywords: nasal NO, children, allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, primary ciliary dyskinesia (PCD), and cystic fibrosis (CF). We describe the use of nNO in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF based on the latest literature. nNO is a noninvasive, clinically applicable test for use in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF. It can be used as a complementary method in the diagnosis of these respiratory diseases and as a monitoring method for the treatment of allergic rhinitis and acute and chronic rhinosinusitis.
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spelling pubmed-106051822023-10-28 Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine Mrkić Kobal, Iva Turkalj, Mirjana Plavec, Davor Children (Basel) Review Nasal nitric oxide (nNO) is a gas synthesized by the inducible and constitutive NO synthase (NOS) enzyme in the airway cells of the nasal mucosa. Like lung nitric oxide, it is thought to be associated with airway inflammation in various respiratory diseases in children. The aim of our review was to investigate the current state of use of nNO measurement in children. A comprehensive search was conducted using the Web of Science and PubMed databases specifically targeting publications in the English language, with the following keywords: nasal NO, children, allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, primary ciliary dyskinesia (PCD), and cystic fibrosis (CF). We describe the use of nNO in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF based on the latest literature. nNO is a noninvasive, clinically applicable test for use in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF. It can be used as a complementary method in the diagnosis of these respiratory diseases and as a monitoring method for the treatment of allergic rhinitis and acute and chronic rhinosinusitis. MDPI 2023-10-09 /pmc/articles/PMC10605182/ /pubmed/37892334 http://dx.doi.org/10.3390/children10101671 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mrkić Kobal, Iva
Turkalj, Mirjana
Plavec, Davor
Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine
title Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine
title_full Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine
title_fullStr Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine
title_full_unstemmed Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine
title_short Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine
title_sort nasal nitric oxide in children: a review of current outreach in pediatric respiratory medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605182/
https://www.ncbi.nlm.nih.gov/pubmed/37892334
http://dx.doi.org/10.3390/children10101671
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