Cargando…
Navigating the ERK1/2 MAPK Cascade
The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological processes including proliferation, cell cycle control, growth, and survival; common across all cell types. Notably, ERK1/2 are implicated in specific processes in a context-dependent manner as in stem cells and pancre...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605237/ https://www.ncbi.nlm.nih.gov/pubmed/37892237 http://dx.doi.org/10.3390/biom13101555 |
_version_ | 1785127025136107520 |
---|---|
author | Martin-Vega, Ana Cobb, Melanie H. |
author_facet | Martin-Vega, Ana Cobb, Melanie H. |
author_sort | Martin-Vega, Ana |
collection | PubMed |
description | The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological processes including proliferation, cell cycle control, growth, and survival; common across all cell types. Notably, ERK1/2 are implicated in specific processes in a context-dependent manner as in stem cells and pancreatic β-cells. Alterations in the different components of this cascade result in dysregulation of the effector kinases ERK1/2 which communicate with hundreds of substrates. Aberrant activation of the pathway contributes to a range of disorders, including cancer. This review provides an overview of the structure, activation, regulation, and mutational frequency of the different tiers of the cascade; with a particular focus on ERK1/2. We highlight the importance of scaffold proteins that contribute to kinase localization and coordinate interaction dynamics of the kinases with substrates, activators, and inhibitors. Additionally, we explore innovative therapeutic approaches emphasizing promising avenues in this field. |
format | Online Article Text |
id | pubmed-10605237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106052372023-10-28 Navigating the ERK1/2 MAPK Cascade Martin-Vega, Ana Cobb, Melanie H. Biomolecules Review The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological processes including proliferation, cell cycle control, growth, and survival; common across all cell types. Notably, ERK1/2 are implicated in specific processes in a context-dependent manner as in stem cells and pancreatic β-cells. Alterations in the different components of this cascade result in dysregulation of the effector kinases ERK1/2 which communicate with hundreds of substrates. Aberrant activation of the pathway contributes to a range of disorders, including cancer. This review provides an overview of the structure, activation, regulation, and mutational frequency of the different tiers of the cascade; with a particular focus on ERK1/2. We highlight the importance of scaffold proteins that contribute to kinase localization and coordinate interaction dynamics of the kinases with substrates, activators, and inhibitors. Additionally, we explore innovative therapeutic approaches emphasizing promising avenues in this field. MDPI 2023-10-20 /pmc/articles/PMC10605237/ /pubmed/37892237 http://dx.doi.org/10.3390/biom13101555 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Martin-Vega, Ana Cobb, Melanie H. Navigating the ERK1/2 MAPK Cascade |
title | Navigating the ERK1/2 MAPK Cascade |
title_full | Navigating the ERK1/2 MAPK Cascade |
title_fullStr | Navigating the ERK1/2 MAPK Cascade |
title_full_unstemmed | Navigating the ERK1/2 MAPK Cascade |
title_short | Navigating the ERK1/2 MAPK Cascade |
title_sort | navigating the erk1/2 mapk cascade |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605237/ https://www.ncbi.nlm.nih.gov/pubmed/37892237 http://dx.doi.org/10.3390/biom13101555 |
work_keys_str_mv | AT martinvegaana navigatingtheerk12mapkcascade AT cobbmelanieh navigatingtheerk12mapkcascade |