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Navigating the ERK1/2 MAPK Cascade

The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological processes including proliferation, cell cycle control, growth, and survival; common across all cell types. Notably, ERK1/2 are implicated in specific processes in a context-dependent manner as in stem cells and pancre...

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Detalles Bibliográficos
Autores principales: Martin-Vega, Ana, Cobb, Melanie H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605237/
https://www.ncbi.nlm.nih.gov/pubmed/37892237
http://dx.doi.org/10.3390/biom13101555
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author Martin-Vega, Ana
Cobb, Melanie H.
author_facet Martin-Vega, Ana
Cobb, Melanie H.
author_sort Martin-Vega, Ana
collection PubMed
description The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological processes including proliferation, cell cycle control, growth, and survival; common across all cell types. Notably, ERK1/2 are implicated in specific processes in a context-dependent manner as in stem cells and pancreatic β-cells. Alterations in the different components of this cascade result in dysregulation of the effector kinases ERK1/2 which communicate with hundreds of substrates. Aberrant activation of the pathway contributes to a range of disorders, including cancer. This review provides an overview of the structure, activation, regulation, and mutational frequency of the different tiers of the cascade; with a particular focus on ERK1/2. We highlight the importance of scaffold proteins that contribute to kinase localization and coordinate interaction dynamics of the kinases with substrates, activators, and inhibitors. Additionally, we explore innovative therapeutic approaches emphasizing promising avenues in this field.
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spelling pubmed-106052372023-10-28 Navigating the ERK1/2 MAPK Cascade Martin-Vega, Ana Cobb, Melanie H. Biomolecules Review The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological processes including proliferation, cell cycle control, growth, and survival; common across all cell types. Notably, ERK1/2 are implicated in specific processes in a context-dependent manner as in stem cells and pancreatic β-cells. Alterations in the different components of this cascade result in dysregulation of the effector kinases ERK1/2 which communicate with hundreds of substrates. Aberrant activation of the pathway contributes to a range of disorders, including cancer. This review provides an overview of the structure, activation, regulation, and mutational frequency of the different tiers of the cascade; with a particular focus on ERK1/2. We highlight the importance of scaffold proteins that contribute to kinase localization and coordinate interaction dynamics of the kinases with substrates, activators, and inhibitors. Additionally, we explore innovative therapeutic approaches emphasizing promising avenues in this field. MDPI 2023-10-20 /pmc/articles/PMC10605237/ /pubmed/37892237 http://dx.doi.org/10.3390/biom13101555 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martin-Vega, Ana
Cobb, Melanie H.
Navigating the ERK1/2 MAPK Cascade
title Navigating the ERK1/2 MAPK Cascade
title_full Navigating the ERK1/2 MAPK Cascade
title_fullStr Navigating the ERK1/2 MAPK Cascade
title_full_unstemmed Navigating the ERK1/2 MAPK Cascade
title_short Navigating the ERK1/2 MAPK Cascade
title_sort navigating the erk1/2 mapk cascade
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605237/
https://www.ncbi.nlm.nih.gov/pubmed/37892237
http://dx.doi.org/10.3390/biom13101555
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